The transient precorneal retention time and low penetration capacity into intraocular tissues are the key obstacles that hinder the ophthalmic drug delivery of many therapeutic compounds, especially for drugs with poor solubility and permeability. To break the stalemate, N-acetyl-L-cysteine functionalized chitosan copolymer (CS-NAC), which exhibit marked bioadhesion and permeation enhancing eff...

We calculate the effective dielectric function for a suspension of small metallic particles immersed in a nematic liquid crystal (NLC) host. For a random suspension of such particles in the dilute limit, we calculate the effective dielectric tensor exactly and show that the surface plasmon (SP)resonance of such particles splits into two resonances, polarized parallel and perpendicular to the NL...

We demonstrate that the process e + e − → tth at the NLC provides a powerful tool for extracting the tt (Yukawa) couplings of the h. In combination with the e + e − → Zh process , an accurate determination of the ZZ coupling of the h is also possible. The resulting ability to distinguish different models of the Higgs sector is illustrated by detailed studies for two-Higgs-doublet models. In ext...

Objective: This work compares the occlusive effect and the penetration enhancement ability of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), through in vitro skin. Methods: SLN and NLC were prepared by high shear homogenization and characterized by size, polydispersity index, zeta potential, morphology and physical stability. Occlusive effect was assessed by an in vitr...

Zerumbone- (ZER-) loaded nanostructure lipid carrier (NLC) (ZER-NLC) prepared for its antileukemia effect in vitro was evaluated for its toxicological effects by observing changes in the liver, kidney, spleen, lung, heart, and brain tissues, serum biochemical parameters, total haemogram, and bone marrow stem cells. The acute toxicity study for ZER-NLC was conducted by orally treating BALB/c mic...

The purpose of the present study was to prepare psoralen-doxorubicin nanostructured lipid carriers (PSO-DOX-NLC) with better physicochemical properties for further study on its multidrug resistance reversal activity on leukemia cells. PSO-DOX-NLC was synthesized by emulsion evaporation and solidification at a low temperature. PSO-DOX-NLC morphology and particle size were examined using transmis...

NLCk is a family of algebras on vertex-labeled graphs introduced by Wanke. An NLC-decomposition of a graph is a derivation of this graph from single vertices using the operations in question. The width of the decomposition is the number of labels used, and the NLC-width of the graph is the smallest width among its NLC-decompositions. Many difficult graph problems can be solved efficiently with ...

BACKGROUND AND THE PURPOSE OF THE STUDY Domperidone (DOM) is a dopamine- receptor (D(2)) antagonist, widely used in the treatment of motion-sickness. The pharmacokinetic parameters of DOM make it a suitable candidate for development of Solid Lipid Nanoparticle (SLN) and Nanostructured Lipide Carrier (NLC). The purpose of the present investigation was to prepare and evaluate DOM loaded solid lip...

Chronic lymphocytic leukemia (CLL) is one of the most common B-cell malignancies in adults, characterized by an accumulation of monoclonal CD5 mature B-cells in lymphoid tissues and peripheral blood (PB). Clonal expansion and invasive migration typically lead to CLL cell involvement in the lymph nodes (LNs), spleen and bone marrow (BM). Signaling from the B-cell antigen receptor regulates multi...

A nitrobenzene liquid-core photonic crystal fiber (NLC-PCF) with eight elliptical air-holes in the innermost ring of cladding is proposed this work, and structure can contribute to flexibly adjusting dispersion constraining core. The appreciable realized by structural parameters NLC-PCF, which characterized three zero-dispersion wavelengths (ZDWs), flat fluctuation fewer than 40 ps nm?1 km?1, h...