background: nicotine can pass through placental blood barrier and accumulate in the developing organs of fetus. also, entering the breast milk, nicotine can have an effect on the neonates. investigations have showed that collagen iv is one of the most important micro vessels basement membrane components. objective:  in this study, the effect of maternal nicotine exposure in pre and postnatal pe...

Tobacco smoking is one of the most serious health problems. Potentially lethal effects nicotine for adults can occur with as little 30 to 60 mg, although severe symptoms arise lower doses. Furthermore, route administration also influences toxicity. Cytisine popular medications in nicotinism treatment. Like nicotine, cytisine a plant alkaloid, signaling through nicotinic acetylcholine receptors....

Previous studies in humans and animals have reported that nicotine administration decreases body weightand caloric intake. Opiate and cigarette have been used concomitantly as drug abuse. The aim of the present study was, therefore, to analyze the effect of chronic co-administration of nicotine and morphine on food intake, body weight and on some feeding-associated peptides. All experiments wer...

Background and Objective: Infertility is a health problem that affects 72.4 million couples worldwide. Infertility can occur due to an unhealthy lifestyle, such as a smoking habit. A cigarette contains nicotine, a toxic compound that can trigger oxidative stress and eventually decrease fertility. Temulawak is a medicinal plant that is rich in antioxidants and anti-inflammatory properties. It ha...

In the present study, the effects of different doses of nicotine on immobility time in mice were tested. Intraperitioneal administration of low doses of nicotine (0.025 mg/kg) decreased, but higher doses (0.8 and 1 mg/kg) increased immobility time. The anti-immobility response induced by low doses of nicotine was inhibited by high doses of the D2 receptor antagonist sulpiride, the central nicot...

Background: Cigarette smoking is associated with impairment of testicular function. Nicotine is a major component of cigarette smoke.In the present study we aimed to study the effect of administration of nicotine-melatonin on sperm parameters in adult mouse. Materials and Methods: Male NMRI mice were divided into 4 groups: 1) control(normal saline) group 2) nicotine treated group 3) melatonin t...

Background: Nicotine exposure causes impaired fertility , ovarian and uterus dysfunction. The pineal hormone melatonin is known as an antioxidant agent. The aim of this study was to investigate the possible protective role of exogen melatonin on altered ovary and endometrium with nicotine. Materials and Methods: Female adult NMRI mice were divided into four groups. The control group received ve...

Background & objectives: The number of waterpipe cafes has considerably grown in Tehran and other cities of Iran. This increase has occurred due to a wrong belief that the use of hookahs is harmless and relatively safe. So, the aim of current study is to investigate the nicotine concentration in the indoor air of the waterpipe and cigarette cafés as well as the biological concentration of nicot...

Nicotine addiction and dependence is a chronic relapsing disease driven by to nicotine. Proactive treatment for all tobacco users, regardless of their readiness quit, recommended. First-line cessation medications include nicotine replacement therapy, bupropion, varenicline. Comprehensive with behavioral interventions pharmacologic therapy increases success rates smoking cessation. Although ther...