recently we have reported that newborn rats are deficient in the key enzymes involved in the biotransformation of aflatoxin bl (afbl), a known hepatocarcinogen. based on these data, in vivo experiments were carried out in order to investigate the bioavailability of this carcinogen in newborn rat tissues. administration of a single dose (i. p.) of [3hlafb 1 to groups of adult and neonatal rats r...

Objective(s): Development of the nervous system in human and most animals is continued after the birth. Critical role of this period in generation and specialization of the neuronal circuits is confirmed in numerous studies. Any pharmacological intervention in this period may result in structural, functional or behavioral abnormalities. In this study, sodium thiopental a GABA mimetic drug was a...

Recently we have reported that newborn rats are deficient in the key enzymes involved in the biotransformation of aflatoxin Bl (AFBl), a known hepatocarcinogen. Based on these data, in vivo experiments were carried out in order to investigate the bioavailability of this carcinogen in newborn rat tissues. Administration of a single dose (i. p.) of [3HlAFB 1 to groups of adult and neonatal r...

We investigated whether prostaglandins regulate endothelial nitric oxide synthase (eNOS) in the pig cerebral vasculature during the neonatal period. Prostaglandins, eNOS mRNA, eNOS protein, and NO production were higher in cerebral microvessels of newborn (1 day old) than in those of adult (6- to 8-month-old) pigs. The treatment of isolated cerebral microvessels of newborn animals with ibuprofe...

Immunoelectrophoretic analysis of 25-day-old newborn and adult rat livers verified the presence of a 6-arc pattern of catalase observed earlier for purified rat hepatic catalase and for liver homogenates. Application of the immunoelectrophoretic method to fetal and newborn liver homogenates revealed a gradual shift from predominantly anodic arcs present in the fetal and early newborn period to ...

The human problems that we will hear about later in this meeting concern feeding babies of unusual weights; first, babies that weigh too little at birth and secondly, babies that weigh too much after birth because they have been over-fed. Somewhat similar situations occur in animals, either in their natural circumstances, or as a result of experimental procedures. I shall describe examples of t...

Neutral endopeptidase (NEP, E.C. 3.4.24.11), a widely distributed ectoenzyme, cleaves and inactivates a variety of biologically active peptides, including the tachykinin, substance P (SP). This study was undertaken to determine whether the modulation of SP airway smooth muscle contraction by NEP is age-dependent. We studied the contractile response of isolated tracheal rings from newborn and 12...

Exposure of the newborn lung to hyperoxia is associated with impaired alveolar development. In newborn rats exposed to hyperoxia and studied at day 14 of life, retinoic acid (RA) treatment improved survival and increased lung collagen but did not improve alveolar development. To determine whether RA treatment during exposure to hyperoxia results in late improvement in alveolarization, we treate...