Antidepressant-like activity of T. kotschyanus has been recently reported by scientists but insufficient attention has ‎so far been devoted to T. kotschyanus, and there is a lack of information on the other neurobehavioral effects and ‎side effects of this species. In the current study, the anticonvulsant, anxiolytic and sedative-hypnotic, effects of ‎Thymus kotschyanus extract on male NMRI mic...

background: with the fast growth in the market of fluorescent lamps, particularly compact fluorescent light, the associated risk of mercury exposure, which is an essential component in all types of fluorescent lamps, has received increasing public attention worldwide. even low doses of mercury are toxic. objective: to study the health consequences of occupational exposure to mercury in workers ...

Sulprofos, disulfoton, azinphos-methyl, methamidophos, trichlorfon, and tebupirimphos were screened for neurotoxic potential, in accordance with U.S. EPA (FIFRA) requirements. Each organophosphate was administered through the diet for 13 weeks to separate groups of Fischer 344 rats at four dose levels, including a vehicle control. For each study, 12 rats/sex/dietary level were tested using a fu...

Perfluorooctanesulfonate (PFOS) is a widely spread environmental contaminant. It accumulates in the brain and has potential neurotoxin effects. Due to chemical properties, PFOS shows persistency in the environment and therefore has potential hazardous effect. The risk of possible intra uterine exposure to PFOS poses a health concern for developmental effects. The goal of this study was survey o...

The phasing out of leaded gasoline for transportation vehicles between 1973 and 1995 and the removal of lead from paint by federal mandate by 1978 have resulted in substantial lowering of mean blood lead levels in all segments of the U.S. population. However, because lead is a persistent metal, it is still present in the environment - in water, brass plumbing fixtures, soil, dust, and imported ...

This investigation was undertaken to study the effect of nitric oxide synthase inhibitor, aminoguanidine on iminodipropionitrile (IDPN)-induced neurobehavioral and vestibular toxicity in rats. The dyskinetic syndrome was produced in male Wistar rats by i.p. injections of IDPN (100 mg/kg) for 6 days. Aminoguanidine was administered orally in the doses of 50, 150 and 300 mg/kg, 60 min before IDPN...

As an effective soil amendment, biochars require a comprehensive ecological evaluation before they can be widely used in agriculture because endogenous contaminants, such as environmentally persistent free radicals (EPFRs), certainly pose risk to invertebrates. In this study, Caenorhabditis elegans (C. elegans) was model organism investigate the neurotoxicity of two rice straw pyrolyzed at 500 ...

Several compelling aruguments have been advanced in support of expanding the use of "behavioral teratology" evaluations as routine components of toxicologic screening procedures. As a basis for development of effective behavioral teratology screening approaches, a conceptual framework is presented which interrelates: (1) changes in relative functional brain capacity with age, (2) possible times...

Cinnabar, a naturally occurring mercuric sulfide (HgS), has long been used in Chinese mineral medicine for more than 2000 years. Although mercury is well-known for its toxicity, whether cinnabar induces neurotoxicity, especially in infants and children, is unknown. The purpose of this study was to explore the neurotoxic effects of low-dose of cinnabar (10 mg/kg/day) on developing mice. The resu...

Iminodipropionitrile (IDPN) produces irreversible behavioral abnormalities characterized by excitation with choreiform and circling movements (ECC) syndrome in rodents. Concomitant exposure to drugs or environmental chemicals has been shown to alter IDPN-induced neurobehavioral toxicity. This investigation was undertaken to study the effect of sodium salicylate (SS) on IDPN-induced behavioral a...