A new laser heating system has been set up to minimize the sample temperature gradients both radially and axially in a diamond anvil cell. A multimode Nd:YAG laser with a relatively flat top of intensity profile allows us to reduce the radial temperature gradient; the axial temperature gradient is minimized by heating samples at both sides. Three dimensional uniform temperatures of 1200 4000 K ...

Conventional PET methods to estimate [(11)C]raclopride binding potential (BP ND) assume that endogenous dopamine concentration does not change during the scan time. However, this assumption is purposely violated in studies using pharmacological or behavioral stimuli to invoke acute dopamine release. When the assumption of steady-state dopamine is violated, conventional analysis methods may prod...

Neodymium (Nd) doped amorphous silicon nitride films with various Si concentrations (Nd:SiNx) were fabricated by reactive magnetron co-sputtering followed by thermal annealing. The time dynamics of the energy transfer in Nd:SiNx was investigated, a systematic optimization of its 1.1 μm emission was performed, and the Nd excitation cross section in SiNx was measured. An active Nd:SiNx micro-disk...

Prediction of the extent and time course of drug-drug interactions (DDIs) between the mechanism-based inhibitor diltiazem (DTZ) and the CYP3A4 substrate midazolam (MDZ) is confounded by time- and concentration-dependent clearance of the inhibitor. Semiphysiologically based pharmacokinetic (PBPK) models were developed for DTZ and MDZ with the major metabolite of DTZ, N-desmethyldiltiazem (nd-DTZ...

Er3+-doped fluorozirconate (ZrF4-BaF2-YF3-AlF3) and oxyfluoroaluminate glasses are successfully prepared here. These glasses exhibit significant superiority compared with traditional fluorozirconate glass (ZrF4-BaF2-LaF3-AlF3-NaF) because of their higher temperature of glass transition and better resistance to water corrosion. Judd-Ofelt (J-O) intensity parameters are evaluated and used to comp...

INTRODUCTION Human eye is a sensitive part of human body with no direct protection and due to its lack of protection against the external heat waves, studying the temperature distribution of heat waves on the human eye is of utmost importance. Various lasers are widely used in medical applications such as eye surgeries. The most significant issue in the eye surgeries with laser is estimation of...

INTRODUCTION The aim of this study was to evaluate the effect of dental surface treatment with Erbium-Doped Yttrium Aluminum Garnet(Er: YAG), Neodymium-Doped Yttrium Aluminium Garnet(Nd: YAG) and Carbon Dioxide Laser (CO2) lasers and sodium ascorbate to recently home bleached enamel by scanning electron microscope (SEM). METHODS Thirty extracted human third molars were selected for this in vi...

introduction: human eye is a sensitive part of human body with no direct protection and due to its lack of protection against the external heat waves, studying the temperature distribution of heat waves on the human eye is of utmost importance. various lasers are widely used in medical applications such as eye surgeries. the most significant issue in the eye surgeries with laser is estimation o...

Passive Q switching of solid-state lasers is usually accomplished with organic dyes or color centers as the saturable absorber. Dyes, however, have poor thermal stability and tend to degrade rapidly. To operate in cw-pumped lasers, dyes require a circulation system. Color centers, such as the color-center LiF crystal, -3 exhibit a fading phenomenon that may limit the period of reliable operatio...

Partial unilateral lentiginosis (PUL) is an unusual pigmentary disorder characterized by numerous lentigines grouped within an area of normal skin. Although treatment is not necessary, many patients with facial PUL seek medical help for cosmetic reasons. There is no established standard treatment for PUL. Conventional lasers may cause postinflammatory hyperpigmentation because keratinocytes are...