نتایج جستجو برای: morphine analgesia formalin test rat

تعداد نتایج: 1112371  

Journal: :Developmental psychobiology 2003
Gordon A Barr Estevan Limon Richard A Luthmann Gordon A Barr Jianxin Cheng Shaoning Wang

Morphine injected locally to the paw of an adult or an infant rat is analgesic. Opiates specific to micro and kappa opioid receptors, and less consistently to delta opioid receptors, given locally to the site of injury in adult animals are also analgesic in a variety of models of inflammatory pain. To determine which opioid receptor(s) are involved in local analgesia in the immature animal, ago...

Journal: :تحقیقات دامپزشکی 0
اسماعیل تمدن فرد گروه علوم پایه، دانشکده دامپزشکی، دانشگاه ارومیه ارفین عظیم پوران دانش آموخته دانشکده دامپزشکی، دانشگاه آزاد اسلامی تبریز بابک بهجت دانش آموخته دانشکده دامپزشکی، دانشگاه آزاد اسلامی تبریز

objective: to investigate the effect of intracerebroventricular injection of histamine on pain induced by subcutaneous iniection of formalin in the left ear of rabbit and the effect of the amine on morphine analgesia and naloxone hyperalgesia. design: experimental study. animals: sixty - six male new zealand white rabbits weighing 2.640.16kg. procedure: intracerebroventricular injections of the...

Mitra Mahmoudi, Mohammad Reza Zarrindast,

In the present study, the effect of GABA (γ-aminobutyric acid) receptor agonists and antagonists on morphine-induced antinociception was investigated in formalin test in rats. Intraperitoneal (i.p.) injection of different doses of morphine (1, 3, 6 and 9 mg/kg) and intracerebroventricular (i.c.v.) injection of different doses of muscimol (0.5, 1 and 2 g/rat) or baclofen (0.25, 0.5 and 1 g/rat) ...

2013
Soo Young Cho A Reum Park Myung Ha Yoon Hyung Gon Lee Woong Mo Kim Jeong Il Choi

BACKGROUND Nefopam, a non-opiate analgesic, has been regarded as a substance that reduces the requirement for morphine, but conflicting results have also been reported. The inhibition of monoamine reuptake is a mechanism of action for the analgesia of nefopam. The spinal cord is an important site for the action of monoamines however, the antinociceptive effect of intrathecal nefopam was not cle...

Journal: :iranian journal of neurology 0
zahra alizadeh department of biology, faculty of sciences, ferdowsi university of mashhad, mashhad, iran. masoud fereidoni department of biology, faculty of sciences, ferdowsi university of mashhad, mashhad, iran. morteza behnam-rassouli department of biology, faculty of sciences, ferdowsi university of mashhad, mashhad, iran. shirin hosseini department of biology, faculty of sciences, ferdowsi university of mashhad, mashhad, iran.

background: usual dosage  of morphine  (10 mg/kg) induces  analgesia  and ultra-low dose (uld) of morphine (1 μg/kg); hyperalgesia, and  c-fibers are also bearing  μ- opioid receptors; here the importance  of c-fibers on pain and  morphine   induced  analgesia/hyperalgesia  is questioned   and  investigated    using   pain   evaluation methods and infant capsaicin treating  for c-fibers lesioni...

2007
Jamal Ghorbi Mohammad Javan Vahid Sheibani Leila Satarian Amir Zarebkohan

Introduction: There is some evidence supporting the reduced activity of integrins following chronic administration of morphine. This reduction might play a role in morphine tolerance development. Manganese binds to the extracellular domain of integrins and makes them to be activated. The effect of integrins activation using manganese on tolerance development to the analgesic effect of morphine ...

2008
Ahmad Asma Hayati Ismail Zalina Than Myo Abdul Aziz Che Badariah Ahmad Azhar Long Idris

Induction of c-fos in the spinal cord due to pain is well established. This study aims to look at the effects of acute swim stress on Fos-like immunoreactivity (FLI) induced by formalin and how it is modulated by ketamine and morphine. Acutely-stressed and non-stressed adult male Sprague Dawley rats were pretreated with intraperitoneal injection of ketamine 5 mg/kg (Ketava, Atlantic Lab), morph...

Journal: :Balkan medical journal 2014
Marjan Kamalpour Masoud Fereidoni Ali Moghimi

BACKGROUND Gap junctions (GJ) are important in pain signalling at the spinal cord level. AIMS The aim of this investigation was to study the effects of GJ on nociception and the analgesic/hyperalgesic effects of morphine following administration of carbenoxolone as a GJ blocker. Male Wistar rats (200-250 g) were divided into three groups: saline i.p., 10 mg/kg and 1 μg/kg i.p. morphine, each ...

2014
Zahra Alizadeh Masoud Fereidoni Morteza Behnam-Rassouli Shirin Hosseini

BACKGROUND Usual dosage of morphine (10 mg/kg) induces analgesia and ultra-low dose (ULD) of morphine (1 µg/kg); hyperalgesia, and C-fibers are also bearing µ-opioid receptors; here the importance of C-fibers on pain and morphine induced analgesia/hyperalgesia is questioned and investigated using pain evaluation methods and infant capsaicin treating for C-fibers lesioning. METHODS Wistar male...

2006
CHRISTOPH STEIN Alexandre R. Oliveira Helena M. T. Barros

The emission of ultrasonic vocalization (USV) by rats submitted to the formalin test has not yet been demonstrated. We performed two experiments to establish the formalin concentration to induce USV and the relationship of USV emission with motor behaviors and the effects of morphine and naloxone on USV during the formalin test. Male Wistar rats were used. In Experiment 1, 3 different groups of...

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