Effects of Monensin on Dry Matter Intake, Milk Production and Healthy Transition Holstein Dairy Cows

Effects of different concentrations of monensin on contraction amplitude (CA) which is the contraction force (CF), initial contraction velocity (ICV), average contraction velocity (ACV) and initial relaxation velocity (IRV) of guinea-pig papillary muscle were studied by using male guinea-pigs. Hearts were removed and papillary muscles were isolated from the right ventricles. The muscles were th...

The Wnt signaling pathway is required during embryonic development and for the maintenance of homeostasis in adult tissues. However, aberrant activation of the pathway is implicated in a number of human disorders, including cancer of the gastrointestinal tract, breast, liver, melanoma, and hematologic malignancies. In this study, we identified monensin, a polyether ionophore antibiotic, as a po...

Field studies of grazing lambs without protozoa in the rumen indicated that live weight gains were 15% higher than in faunated lambs (Bird &nd Leng 1985). Poos et al. (1979) reported that monensin decreased protozoa1 populations in the rumen but Leng et al. (1984) found no effect of monensin on half life or growth rate of protozoa. However in previous studies (Habib, G. & Preston, T.R. 1984 unp...

Toxic effects of monensin, a polyether antibiotic mainly used as a coccidiostat, have been described in a wide range of animals. The present study was performed to investigate the toxic effects of monensin in goats. Seven adult goats were administered sodium monensin, 13.5 mg kg(-1), daily for five consecutive days via gastric gavage. Monensin toxicity was evaluated by clinical signs, serum bio...

Two series of trials were conducted to evaluate alternative methods of administering monensin to pasture cattle. In a series of five trials, monensin was incorporated into supplements at 440 mg/kg to provide an average intake of 200 mg X head-1 X d-1 for growing cattle on pasture. Comparisons were made between daily and alternate-day feeding of the supplements. A control treatment consisting of...

Gram-negative, ionophore-resistant ruminal bacteria and Gram-positive, ionophore-sensitive species bound similar amounts of [14C]lasalocid, but neither group bound large amounts of [14C]monensin. Membrane vesicles also bound more lasalocid than monensin (P < .05). The binding was first-order at low cell or vesicle concentrations and saturable at high cell or vesicle densities. Streptococcus bov...

Monensin is a common feed additive used in various countries, where 1 of the associated benefits for use in beef cattle is improved efficiency of energy metabolism by the rumen bacteria, the animal, or both. Modeling fermentation-altering supplements is of interest, and thus, it is the purpose of this paper to quantify the change in VFA profile caused by monensin dose in high-grain-fed beef cat...

The aim of this study was to determine the relationship between gas produced through in vitro gas production test and microbial fuel cell (MFC) technique and introduce new assay for evaluation of ruminants feedstuffs. The treatments were 1) control diet (without whole cottonseed, monensin and vitamin E; CD), 2) diet containing 20.00% whole cottonseed (CSD), 3) diet including 20.00% who...

1. Monensin (CAS 17090-79-8, CAS 22373-78-0 for sodium salt) is a polyether antibiotic from the group of carboxylic ionophores produced by Streptomyces cinnamonensis. Monensin is used as the sodium salt. It is composed of the analogues A, B, C and D with monensin A being the major component (equivalent to 98%). The intended use as a veterinary medicinal product in lactating dairy cattle is as a...