نتایج جستجو برای: mir 103a 3p

تعداد نتایج: 49246  

Journal: :Journal of the Endocrine Society 2021

Abstract Circulating microRNA (miRNA), a non-coding RNA molecule, is the potential biomarker for bone and mineral metabolism. Primary hyperparathyroidism (PHPT) one of leading causes secondary osteoporosis. After parathyroidectomy, BMD improves as parathyroid hormone (PTH) decreases in patients with PHPT but degree recovery vary greatly among patients. Biomarkers which are able to predict posto...

2017
Douglas F Dluzen Yoonseo Kim Paul Bastian Yongqing Zhang Elin Lehrmann Kevin G Becker Nicole Noren Hooten Michele K Evans

Oxidative stress is thought to contribute to aging and age-related diseases, such as cardiovascular and neurodegenerative diseases, and is a risk factor for systemic arterial hypertension. Previously, we reported differential mRNA and microRNA (miRNA) expression between African American (AA) and white women with hypertension. Here, we found that the poly-(ADP-ribose) polymerase 1 (PARP-1), a DN...

MicroRNAs (miRNAs) have emerged as essential gene expression regulators associated with human diseases such as colorectal cancer (CRC). The purpose of this study was to evaluate the expression of miR-330-3p and its target gene BMI1 in tissue samples of patients with CRC, polyp, and healthy adjacent tissue samples and their association with clinicopathological and demographic factors such as age...

Journal: :Obstetrics, Gynecology and Reproduction 2023

Aim: comparative analysis of the expression profile plasma microRNAs and target genes in patients with complicated pregnancy. Materials Methods. A prospective observational study parallel groups was carried out. The included 73 women divided into three groups: main group – 42 preeclampsia (PE), comparison 12 pregnant fetal growth retardation (FGR), control 19 clinically healthy uncomplicated An...

Journal: :European Psychiatry 2023

Introduction There are currently no diagnostic or treatment-guiding biomarkers for major depressive disorder (MDD). Microribonucleic acids (miRNA) may facilitate understanding the reorganisation of gene expression networks in MDD. Identifying miRNA and target mRNA pathways that contribute to MDD open new therapeutic avenues, such as inhibiting endogenous administering exogenous miRNA. Objective...

Journal: :Bioscience, Biotechnology, and Biochemistry 2021

ABSTRACT Osteoarthritis (OA) seriously affects people's quality of life due to joint pain, stiffness, disability, and dyskinesia worldwide. Long noncoding RNA zinc finger antisense 1 (ZFAS1) is downregulated tightly associated with proliferation, migration, apoptosis, matrix synthesis chondrocyte in OA. However, the molecular mechanisms ZFAS1 OA remain unknown. The expression correlation betwee...

Journal: :Journal of Crohn's and Colitis 2023

Abstract Background Emerging evidence suggests that epithelial cell-derived microRNAs (miRNA) are involved in the pathogenesis of inflammatory bowel disease; however, as now specific implications real clinical practice, especially relation to biologics use yet far-fetched. Therefore, we tried investigate cell derived miRNA signatures related and endoscopic activity Crohn’s disease (CD) patients...

2018
Kirsten Lindner Ann-Kathrin Eichelmann Christiane Matuszcak Damian James Hussey Jörg Haier Richard Hummel

BACKGROUND Resistance towards chemotherapy is a major obstacle in the treatment of esophageal squamous cell carcinoma (ESCC). We investigated the role of specific microRNAs in chemotherapy resistance and tumor biology. METHODS We selected three microRNAs from characteristic microRNA signatures of resistant ESCC (hsa-miR-125a-5p, hsa-miR-130a-3p, hsa-miR-1226-3p), and hsa-miR-148a-3p. Effects ...

Journal: :hepatitis monthly 0
nadia mohamed el-guendy department of cancer biology, national cancer institute, cairo university, cairo, egypt reham helwa department of zoology, faculty of science, ain shams university, cairo, egypt medhat salah el-halawany department of zoology, faculty of science, cairo university, cairo, egypt shimaa abdel rahman ali department of cancer biology, national cancer institute, cairo university, cairo, egypt marwa tantawy aly research department, children’s cancer hospital, cairo, egypt nelly hasan alieldin department of biostatistics and cancer epidemiology, national cancer institute, cairo university, cairo, egypt

conclusions the identified expression profiles of some examined mirnas might offer important points to consider for the treatment of naive patients and the management of chronically infected hcv patients in egypt and around the world. results our results revealed differential expression levels of the analyzed mirnas compared to the normal controls. twenty-seven mirnas (including mir-105, mir-14...

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