BACKGROUND Temozolomide (TMZ) induces a G2/M cell cycle arrest and is used for treatment of paediatric tumours, especially neuroblastomas. Patients treated with TMZ frequently receive midazolam for sedation prior to surgery and other interventions. Previous studies suggested both cytoprotective and apoptosis-inducing properties of midazolam. Therefore, the impact of midazolam on TMZ-induced cyt...

Objectives − The aim of our article is to highlight the adverse effects midazolam, which causes abnormal behavior and a paradoxical behavioral reaction, although it used for sedation seizure control, as well preoperative procedure-related in neonates.Case Presentation We report myoclonic seizure-like activity four preterm neonates, who received intravenous midazolam before laser photocoagulatio...

BACKGROUND Although midazolam administration may occasionally induce a paradoxical episode, such as threatened crying and violent behavior in children, systematic studies on the causes of paradoxical reaction are limited. We investigated the effect of children's age and a dose of midazolam on the paradoxical reaction. METHODS A total of one hundred sixty four children of 1-3 years and 3-5 yea...

Objective: The objective of the study was to compare effects dexmedetomidine versus midazolam-fentanyl on post-operative recovery, sedation, analgesia, and hemodynamic parameters in patients undergoing middle ear surgery under local anesthesia. Methods: Seventy-two were randomly divided into two equal groups - Group D (dexmedetomidine) MF (midazolam fentanyl). Intra operative heart rate, mean b...

background: although some patients can tolerate colonoscopy procedure using fentanyl/ midazolam without any sedation and analgesic requirements but some patients may require additional sedation with benzodiazepines. we performed the present study to compare the effect of paracetamol/midazolam with fentanyl/ midazolam. methods: in a clinical trial, 96 patients aged 18 to 75 years old, who were c...

Fentanyl decreases clearance of midazolam administered i.v., but the mechanism remains unclear. To elucidate this mechanism, we have investigated the effect of fentanyl on metabolism of midazolam using human hepatic microsomes and recombinant cytochrome P450 isoforms (n = 6). Midazolam was metabolized to l'-hydroxymidazolam (l'-OH MDZ) by human hepatic microsomes, with a Michaelis-Menten consta...

BACKGROUND This study evaluates possible circadian rhythms during prolonged midazolam infusion in 27 pediatric intensive care unit (PICU) children under mechanical ventilation. METHODS Blood samples for midazolam and 1-OH-midazolam assay were collected throughout the infusion at different times of the day. The blood pressure, heart rate and body temperature were recorded every hour for the rh...

BACKGROUND The use of midazolam for dental care in patients with intellectual disability is poorly documented. The purpose of this study was to determine which method of premedication is more effective for these patients, 0.15 mg/kg of intramuscular midazolam or 0.3 mg/kg of oral midazolam. MATERIAL AND METHODS This study was designed and implemented as a non-randomized retrospective study. T...

aim and background:   adding new supplements when performing spinal anesthesia can increase the duration of analgesia. the aim of the present study has been to compare intrathecal midazolam and tramadol with the conventional method for postoperative pain and shivering control after elective caesarean section. methods and materials:   in this double-blind clinical trial, 210 asa class i,ii women...

INTRODUCTION Midazolam is used routinely to sedate patients in the intensive care unit (ICU). We suspected that midazolam over-sedation was occurring in the ICU of the Guy's and St. Thomas' Trust and that it could be difficult to differentiate this from underlying neurological damage. A sensitive assay for detecting midazolam and 1-hydroxymidazolam glucuronide (1-OHMG) in serum was developed an...