Gentamicin is an effective widely used antibiotic, but the risk of nephrotoxicity and oxidative damage limit its long-term use. Hence, the current study aims to elucidate such hazardous effects. To achieve the study aim male Wistar albino rats (Rattus norvegicus) were exposed to gentamicin to investigate the resultant blood chemical changes and renal histological alterations. In comparison with...

The new Oxford Classification of the Pathology of IgA nephropathy originated from an international collaborative effort of the Working Group of the International IgA Nephropathy Network and Renal Pathology Society. It provides a new common language to categorizing glomerular and tubulo-interstitial lesions in IgA nephropathy having a proved effect on progression. Although retrospective in desig...

Objective(s): This study aims to evaluate the activity of mangosteen peels extract (MPE) as protection agent on induced-glucose mesangial cells (SV40 MES 13 cell line (Glomerular Mesangial Kidney, Mus Musculus)).  Materials and Methods: MPE was performed based on maceration method. Cytotoxic assay was performed based on MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophen...

INTRODUCTION The current prevalence of glomerulonephritis in patients with hepatosplenic schistosomiasis mansoni in Brazil was evaluated. METHODS Sixty three patients (mean age 45.5 ± 11 years) attending the outpatient infectious disease clinic of a University Hospital in Belo Horizonte, Brazil, from 2007 to 2009, were consecutively examined and enrolled in the present investigation. Diagnosi...

The report presents the results of investigations carried out in 63 patients (49 children and 14 adults) with thin glomerular basement membrane disease. Of 49 children, 13 came from nine families with family members suffering from kidney diseases (mostly manifested by haematuria). In the group of children, the most frequent initial clinical symptom (noted in 29 cases) was isolated haematuria, m...

CASE A 38-year-old man was admitted to hospital for evaluation of kidney dysfunction. His serum creatinine on admission was 1.6 mg/dL. His past medical history was unremarkable and there was no family history of kidney dysfunction. His blood pressure was 130/80 mm Hg, and he had no history of hypertension. Physical examination revealed only mild pedal edema. On urinalysis, there were microscopi...

BACKGROUND The Oxford classification of IgA nephropathy (IgAN) provides a useful tool for prediction of renal prognosis. However, the application of this classification in children with IgAN needs validation in different patient populations. METHODS A total of 218 children with IgAN from 7 renal centers in China were enrolled. The inclusion criteria was similar to the original Oxford study. ...

BACKGROUND The significance of IgM deposits in glomerular mesangium has been controversial since they were first described due to the variations in the both the definitions used and described impact on clinical outcome. The aim of our study was to evaluate the significance of the IgM deposits in the glomerular mesangium for outcomes of nephrotic syndrome (NS) in children. METHODS Forty-five c...

IntroductionIgA nephropathy (IgAN) is a progressive autoimmune kidney disease and leading cause of glomerular that can result in failure (KF). Median age at diagnosis 35-37 years close to 50% patients will progress KF within 20 years. We aimed enhance the understanding renal histology chronic (CKD) stage time IgAN using large real-world biopsy cohort.MethodsThis retrospective cohort study evalu...

Objective : to study the effect of total expression vascular endothelial growth factor A (VEGF A), tissue β1 (TGF-β1) and monocytic chemoattractant 1 (MCP-1) on course glomerulonephritis. Material methods was a prospective (12-month) open comparative clinical morphological with inclusion 75 patients aged 18 years (males - 52, females 23) glomerulonephritis in acute stage. All were initially exa...