objective(s): nitric oxide (no), a product of inducible nitric oxide synthase (inos), contributes in germ cell apoptosis. this study was aimed to evaluate the effects of aloe vera gel (avg) on male wistar rat reproductive organ, serum no level, and expression of inos gene in leydig cells. materials and methods:adult male wistar rats (n=36) were used for experiments in three groups. the experime...

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background: the recently reported resistance to antimalarials contributes to making the control of ma­laria more difficult. there is a need to evaluate the current antimalaria regimens to prevent this emerging problem. the aim of this study was to determine dihydrofolate reductase-thymidylate synthase gene mu­tation ( pvdhfr ) regarding antifulate resistance in plasmodium vivax . methods : from...

background: the wnt/β- the wnt/β-catenin signaling pathway is involved in many developmental processes in both fetal and adult life; its abnormalities can lead to disorders including several types of cancers and malfunction of specific cells and tissues in both animals and humans. its role in reproductive processes has been proven. objective: this study was designed to evaluate the expression o...

this study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (ts) inhibitor. the designed scaffold is a combination of nucleobase, amino acid and aziridine structures. the candidates are docked into ts and three dna double strand structures and evaluated based on their binding interaction energies and ligand efficienci...

The ATP synthase in mitochondria was responsible for the synthesis of to provide chemical energy cell achieve metabolism. point mutation at mitochondrial DNA nt 8993(T>C and T>G) disrupted normal cellular mechanism synthase, causing a deficiency production synthesis. 8993 causes replacement leucine amino acid with an arginine(aL156R), changing sequence ATP6 gene, which inefficiency c-subu...

objective(s): investigation of acute effect on cellular bioenergetics provides the opportunity to characterize the possible adverse effects of drugs more comprehensively. this study aimed to investigate the changes in biochemical and biophysical properties of heart mitochondria induced by captopril and nifedipine antihypertensive treatment. materials and methods: male, 12-week-old wistar rats i...

Metabolic syndrome includes the following symptoms: obesity, hyperlipidemia, hypertension, insulin resistance, and cardiovascular disease. The purpose of this review is to elucidate role adipokines in regulation L-arginine-NO-synthas-NO signaling pathway pathogenesis metabolic syndrome. main questions raised are: how adipokine secretion changes, level their receptors regulated, which pathways a...

Die Sesterviolen-Synthase aus Streptomyces violens wurde identifiziert und repräsentiert die zweite bekannte Sesterterpen-Synthase Bakterien. Es wurden Isotopenmarkierungsexperimente in Verbindung mit DFT-Rechnungen durchgeführt, detaillierte Einblicke ihren komplexen Cyclisierungsmechanismus lieferten. Enzym-Engineering durch ortsgerichtete Mutagenese ermöglichte den Zugang zu einer hochergieb...