Terminally hydroxylated polypropylene (PP) synthesized by a chain transfer method was grafted to graphene oxide (GO) at the chain end. Thus obtained PP-modified GO (PP-GO) was melt mixed with PP without the use of a compatibilizer to prepare PP/GO nanocomposites. Mechanical and electrical properties of the resultant nanocomposites and reference samples that contained graphite nanoplatelets, par...

Almost all the submicron metal particles in the glass coating of breccia 15286 are rounded and Contain two phases, metal and sulfide tEeS). The Ni content of the metal phase as determined by scanning transmission electron microscope X-ray analysis ranged from 9.4 to 15.5 tvt. The sulfide was nearly stoichiometric troilite containing up to 1.3 wt’ Ni. The close chemical and mi crostructural simi...

A novel mixing approach for achieving a good dispersion of multi-walled carbon nanotubes (MWCNTs) in ethylene- propylene diene monomer (EPDM) matrix has been investigated. In this approach EPDM was modified with vinyltrimethoxysilane (VTMS) during melt mixing. In addition the effect of MWCNT concentration on mechanical and rheological properties of modified EPDM has been studied. The formulated...

Methods of preparation and application of amorphous form are well established but it is equally important to note that devitrification of amorphous drugs has limited their applications. Present study was performed to investigate mechanism for amorphous drug stabilization using Gelucire in comparison with polyvinylpyrrolidone (PVP). Etoricoxib and celecoxib were taken as model drugs for this stu...

This work studied artemether (ARTM) solid dispersion (SD) formulation using mixture of polymer excipient Soluplus, PEG 400, Lutrol F127, and Lutrol F68 melts at temperatures lower than the melting point of ARTM using a laboratory-size, single-screw rotating batch extruder. The effects of three surfactants PEG 400, Lutrol F127, and Lutrol F68 and parameters like mixing temperature, screw rotatin...

Molecular dynamics (MD) simulations were performed on a model polymer–nanoparticle composite (PNPC) consisting of spherical nanoparticles in a bead-spring polymer melt. The polymer-mediated effective interaction (potential of mean force) between nanoparticles was determined as a function of polymer molecular weight and strength of the polymer–nanoparticle interaction. For all polymer–nanopartic...

Many commodity plastics, such as thermoplastic polyurethanes (PUs), require reinforcement for use commercial products. Cellulose nanocrystals (CNCs) offer a “green” and scalable approach to polymer they are exceptionally stiff, recyclable, abundant. Unfortunately, achieving efficient CNC of PUs with industrial melt processing techniques is difficult, mostly due the incompatibility hydrophobic P...

The objective of this study was to determine if a high Tg polymer (Eudragit(®) S100) could be used to stabilize amorphous domains of polyethylene oxide (PEO) and hence improve the stability of binary polymer systems containing celecoxib (CX). We propose a novel method of stabilizing the amorphous PEO solid dispersion through inclusion of a miscible, high Tg polymer, namely, that can form strong...

Eggshell (ES), a waste byproduct from food processing and hatcheries, contains 95% calcium carbonate (CC), making it a potentially attractive, less expensive substitute for commercial CC. Past work used complex grinding–sieving and/or chemical modification steps to aid in dispersing ES in polymers such as polypropylene (PP). Both steps add to the cost and reduce the green aspect of the composit...

The aim of this study was to evaluate the suitability of Raman spectroscopy as a Process Analytical Technology (PAT) tool for the in-line determination of the active pharmaceutical ingredient (API) concentration and the polymer-drug solid state during a pharmaceutical hot-melt extrusion process. For in-line API quantification, different metoprolol tartrate (MPT)--Eudragit® RL PO mixtures, conta...