INTRODUCTION A retrospective study of melanocytic naevi was undertaken to assess the degree of clinico-pathological correlation and incidence of histological atypia. MATERIALS AND METHODS The case records from January to March 1996 of all patients with histologically diagnosed melanocytic naevi at the National Skin Centre were analysed. RESULTS Of the 240 lesions removed from 167 patients, ...

Having multiple melanocytic naevi (< 50 naevi) is one of the strongest risk factors for melanoma. However, the epidemiology in adults is unclear. This comprehensive dermatological status investigation of 1,932 birth-cohort study cases aged 46 years analysed the prevalence of multiple melanocytic naevi and their association with sex, socioeconomic status (education) in childhood and adulthood, s...

Lateral labial melanocytic nevus or mole has cosmetic value among young or middle aged Iranian ladies particularly those with fair complexion. I describe auto transplantation of a melanocytic nevus from a remote area of the body to lateral labial skin. After selection of a 3-mm nevus, both donor and recipient sites were anesthetized. A punch with a diameter comparable to the diameter of t...

BACKGROUND Melanocytic proliferations are common in horses but the diagnosis of malignancy is not always straightforward. To improve diagnosis and prognosis, markers of malignancy are needed. Receptor for activated C kinase 1 (RACK1) protein may be such a marker. RACK1 was originally found to characterize malignant melanocytic lesions in the Melanoblastoma-bearing Libechov minipig (MeLiM) and, ...

study in Japan. Arch Dermatol. 2004;140(10):1233-1238. 6. Altamura D, Zalaudek I, Sera F, et al. Dermoscopic changes in acral melanocytic nevi during digital follow-up. Arch Dermatol. 2007;143(11):13721376. 7. Ozdemir F, Karaarslan IK, Akalin T. Variations in the dermoscopic features of acquired acral melanocytic nevi. Arch Dermatol. 2007;143(11):13781384. 8. Minagawa A, Koga H, Saida T. Dermos...

The main objective of surface microscopy is the early and accurate diagnosis of melanoma in its initial phases of evolution and infiltration. Since the development of the dermatoscope in the 1990's, surface microscopy has become a simple technique. Differential diagnosis of pigmented skin lesions can be achieved with a diagnostic sensitivity of about 90 percent, and the proper differentiation o...

BACKGROUND Hereditary syndromes frequently need the cooperation of different specialties to increase diagnostic competence. Multiple cutaneous and uterine leiomyomatosis syndrome is a rare autosomal dominant disorder caused by the mutations of the fumarate hydratase gene, demonstrated in 80 to 100 percent of affected individuals. This can be linked to an increased risk of renal cancer in both s...

Melanocytic nevus is common pigmented skin tumor, but it has rare occurrence near the external auditory canal. A skin graft is required if a wide surgical excision is performed for the nevi occurring near the external auditory canal. A CO2 laser was considered to be a good alternative for the removal of melanocytic nevus in this area. We herein report a case of compound nevus occurring near the...

Background: Although cyclin-dependent kinase 2 (CDK2) is known to be upregulated in certain cancers, its spatial expression pattern melanocytic tumors has remained unknown. Objective: To characterize CDK2 benign and malignant proliferations. Methods: We performed immunohistochemistry (IHC) on normal skin a tumor panel comprising over 200 congenital nevi, dysplastic melanomas situ, invasive mela...

Various benign and malignant non-melanocytic tumors, including skin appendage tumors, sometimes accompany non-neoplastic melanocytes, and this phenomenon has been described as “melanocytic colonization” [1-7]. Porocarcinoma is a rare skin appendage carcinoma related to the sweat gland duct, originally described by Pinkus and Mehregan in 1963 [8]. Its incidence is reported to be 0.004% of skin b...