Herpesviruses form different gH/gL virion envelope glycoprotein complexes that serve as entry complexes for mediating viral cell-type tropism in vitro; their roles in vivo, however, remained speculative and can be addressed experimentally only in animal models. For murine cytomegalovirus two alternative gH/gL complexes, gH/gL/gO and gH/gL/MCK-2, have been identified. A limitation of studies on ...

Developing Xenopus laevis experience two periods of muscle differentiation, once during embryogenesis and again at metamorphosis. During metamorphosis, thyroid hormone induces both muscle growth in the limbs and muscle death in the tail. In mammals, the muscle creatine kinase (MCK) gene is activated during the differentiation from myoblasts to myocytes and has served as both a marker for muscle...

Skeletal muscle resistance to the key metabolic hormones, leptin and insulin, is an early defect in obesity. Suppressor of cytokine signaling 3 (SOCS3) is a major negative regulator of both leptin and insulin signaling, thereby implicating SOCS3 in the pathogenesis of obesity and associated metabolic abnormalities. Here, we demonstrate that SOCS3 mRNA expression is increased in murine skeletal ...

Introduction: The specification formalism employed in model checking is usually some flavour of temporal or process algebraic language that expresses properties of the behavioural aspects of a system. Knowledge [5] is a modality that is orthogonal to the behavioural dimension, capturing properties of information flow. Logics of knowledge have been shown to be a useful framework for the analysis...

In mobile computing, a computer which in 1970 filled several large rooms, has been reduced in size so that it is now slips neatly into your pocket or is bound to your wrist. It has taken the last decade for this feat of engineering to come to fruition. Meanwhile, we have also experienced many evolutions and revolutions in the software systems and communication fields. The most dramatic of these...

Cellular cardiomyoplasty using skeletal myoblasts may be beneficial for infarct repair. One drawback to skeletal muscle cells is their lack of gap junction expression after differentiation, thus preventing electrical coupling to host cardiomyocytes. We sought to overexpress the gap junction protein connexin43 (Cx43) in differentiated skeletal myotubes, using retroviral, adenoviral, and plasmid-...

Sanitasi adalah upaya yang dilakukan untuk memelihara dan melindungi kebersihan lingkungan. Kondisi lingkungan bersih, aman sehat sangat dibutuhkan oleh masyarakat. Masyarakat Desa Gantarang masih banyak belum mengetahui atau memahami beberapa hal terkait kesehatan khususnya pengelolaan sampah dapat mengganggu kesehatan. Oleh karena ini penyuluhan tentang pentingnya sanitasi di Kecamatan Kelara...

This study used mice with muscle-specific overexpression of PGC-1α, a transcriptional coactivator that promotes mitochondrial biogenesis, to determine whether increased oxidative potential facilitates metabolic improvements in response to lifestyle modification. MCK-PGC1α mice and nontransgenic (NT) littermates were fed a high-fat diet (HFD) for 10 weeks, followed by stepwise exposures to volun...

Transcriptional regulatory element X (Trex) is a positive control site within the Muscle creatine kinase (MCK) enhancer. Cell culture and transgenic studies indicate that the Trex site is important for MCK expression in skeletal and cardiac muscle. After selectively enriching for the Trex-binding factor (TrexBF) using magnetic beads coupled to oligonucleotides containing either wild-type or mut...