The therapeutic effects of both cytokine-secreting tumor vaccine and DNA vaccine were studied using mouse MBT-2 bladder cancer cells as a model. Cytokine-secreting MBT-2 cells were obtained by infecting cells with retroviral particles containing interleukin (IL) 2-, IL-4-, or granulocyte-macrophage colony-stimulating factor (GM-CSF)-expression vector. The MBT-2-IL-2 cells were not tumorigenic i...

The paper is an experience report on the introduction of model-based testing (MBT) approaches in industrial projects. It reflects the author’s subjective view on that matter that he gained in various software development projects at Siemens. Existing MBT approaches are classified and evaluated according to their importance in recent projects. In addition the necessary requirements and efforts t...

BACKGROUND Borderline personality disorder (BPD) is characterised by severe instability in emotions, identity, relationships and impulsive behaviour. One contributing factor to BPD is deficient mentalizing-our ability to understand the mental states of others and ourselves. Psychotherapies can be effective at reducing symptoms of BPD but effects are small. Innovative ways of enhancing existing ...

BACKGROUND The Polycomb group (PcG) of proteins is a family of important developmental regulators. The respective members function as large protein complexes involved in establishment and maintenance of transcriptional repression of developmental control genes. MBTD1, Malignant Brain Tumor domain-containing protein 1, is one such PcG protein. MBTD1 contains four MBT repeats. METHODOLOGY/PRINC...

This article describes a self-healing coating for corrosion protection of metals, which combines two different types of self-healing mechanisms in one coating with multiple-healing functionality. 2-Mercaptobenzothiazole (MBT) was loaded into layered double hydroxide (LDH) carriers that were mixed into an acrylated polycaprolactone polyurethane-based shape-recovery coating and applied on hot-dip...

Polycomb group (PcG) proteins repress transcription by modifying chromatin structure in target genes. dSfmbt is a subunit of the Drosophila melanogaster PcG protein complex PhoRC and contains four malignant brain tumour (MBT) repeats involved in the recognition of various mono- and dimethylated histone peptides. Here, we present the crystal structure of the four-MBT-repeat domain of dSfmbt in c...

This intervention aimed to improve Badminton-specific functional performance of an elite under-19 player (18 years) via a single-weekly resistance and plyometric training (RPT) session for 8-weeks. The athlete’s ‘response-to’ and ‘withdrawal-from’ the RPT were assessed. The athlete (stature: 1.77 m, mass: 81.5 kg) completed the RPT intervention throughout a competitive season. Performance testi...

Mentalization-based treatment (MBT) is an evidence-based treatment for adults suffering from borderline personality disorder. Different adaptations of MBT for adolescents have been described, but almost none of these have been systematically evaluated so far. This article presents pilot data from a feasibility study of an adaptation of inpatient MBT for adolescents with borderline symptoms (MBT...

INTRODUCTION Multimodal approaches in behavioral treatment have gained recent interest, with proven efficacy for migraine. The utility of the Internet has been demonstrated for behavioral treatment of headache disorders, but not specifically for migraine. The aim of the study was to develop and evaluate an Internet-based multimodal behavior treatment (MBT) program for migraine and to test hand ...

Model-based testing (MBT) generates test cases by analysing a formal model of the system under test (SUT). In many MBT methods, these test cases are too abstract to be executed. Therefore, an executable representation of them is necessary to test the SUT. So far, the MBT community has focused on methods that automate the generation of test cases, but less has been done in making them executable...