Background: Celery (Apium graveolens) has many therapeutic effects.This plant has many phytoestrogens that can affect on the reproductive endocrine system and can reduce fertility .In this study, hydro alcoholic extracts of celery leaves on the pituitary-gonad axis in young male l mice of Balb/C was investigated. Materials and Methods: The samples were randomly divided into 5 groups (three trea...

Background: Spermatogenesis is under the control of variety of factors, which include mast cells. Any changes in testicular mast cells’ number and distribution resulting in deterioration of comlex regulation and fine-turning of spermatogenesis. Increased number of mast cells and their abnormal spread pattern have been described in the testis with fertility disturbances. Mast cells’ tryptase enz...

Background: Leukocyte infiltration into the central nervous system (CNS) in diseases like multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE) have been implicated in subsequent disease pathogenesis and progression. It suggested that vitamin D3 (active form of vitamin D) ameliorates the symptoms of EAE when administered after the onset of clinical sings. The aim of this s...

Background & aims In the last decade, role of microbiota–gut–brain axis in eating behavior and anxiety-depressive disorders has gained increasing attention. Although a gut microbiota dysbiosis been reported anorectic patients, its pathophysiological remains poorly understood. Thus, we aimed to characterize potential by evaluating effects depletion Activity-Based Anorexia (ABA) mouse model both ...

background: exercise has positive and negative effects on immune system. herein, we would like to investigate the effects of incremental aerobic training and fish oil supplementation on the plasma levels of crp, cpk and il-17 in trained mice. one of the major roles of immune system is to produce soluble or cellular components that provide the immunity against inflammatory agent. the purpose of ...

Background Nonyl phenol (NP) has been considered an endocrine disrupting substance causing reproductive dysfunction and increase in reactive oxygen species production in different organs including testis. vitamin E (VitE) is a potent scavenger of free radicals and is able to prevent the membrane damage mediated by free radicals The aim of this study was to elucidate the protective effects of Vi...

Pharmacokinetics of leptin in mammals has not been studied in detail and only one study has examined more than one time point in non-mutant mice and this was in a female mice. This is the first study to describe leptin distribution over a detailed time course in normal male mice. A physiologic dose (12 ng) of radiolabelled leptin was injected into adult male mice via the lateral tail vein and t...