Successful human vaccination by synthetic malarial sporozoite peptides may depend on the choice of an appropriate carrier. Tetanus toxoid (TT) has been proposed because of its safe and widespread use in humans. Paradoxically, however, prior exposure to this toxoid vaccine could produce specific epitopic suppression against synthetic malarial peptides conjugated to this same protein as carrier. ...

At least a million people, mainly African children under 5 years old, still die yearly from malaria, and the burden of disease and death has increased. Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is one of the most promising blood-stage malarial vaccine candidates. However, the allelic polymorphism observed in this protein is a potential stumbling block for vaccine development. To ...

BACKGROUND Atopic diseases are more prevalent in industrialized countries than in developing countries. In addition, significant differences in the prevalence of allergic diseases are observed between rural and urban areas within the same country. This difference in prevalence has been attributed to what is called the 'hygiene hypothesis'. Although parasitic infections are known to protect agai...

bred outdoors in malaria-endemic areas is not uncommon. However, with the exception of P. knowlesi, it is my understanding that malarial organisms found in cynomolgus monkeys do not pose a major zoonotic concern (although this can always change). Furthermore, it is my understanding that P. vivax does not infect macaques, including cynomolgus monkeys. Other malarial parasites of cynomolgus monke...

This study aimed to determine the changes in lymphocyte surface markers and cytokine profiles during a malarial infection in a mouse model of malaria. Mononuclear cells obtained from the spleens of the mice infected with Plasmodium berghei (P. berghei) were stained with anti-mouse CD3, anti-mouse CD4, anti-mouse CD8, anti-mouse CD19, anti-mouse CD152, anti-mouse pan natural killer (NK), anti-mo...

The enolase protein of the human malarial parasite Plasmodium falciparum has recently been characterized. Apart from its glycolytic function, enolase has also been shown to possess antigenic properties and to be present on the cell wall of certain invasive organisms, such as Candida albicans. In order to assess whether enolase of P. falciparum is also antigenic, sera from residents of a region ...

1. Two important methods for the study of malarial pigment are described. (a) A method for obtaining a solution of malarial pigment from fixed tissues without the removal of a trace of hemoglobin from the red blood corpuscles. (b) A method for obtaining an iron reaction in malarial pigment. 2. By comparing the bleach reactions and solubility of melanins and malarial pigment, the dissimilarity o...

BACKGROUND This study was conducted in a private clinic to report frequency, presentation and management of malaria in children presenting with fever. METHODS 160 Children of age varying from 42 days to 15 years were included in this study, during a period of 1999-2004. RESULTS AND CONCLUSIONS Malaria was confirmed in 154 cases, including 114 male and 46 female children. In 6 cases malarial...

Set in an unspecified time in the future, this medical thriller takes the readers through a wondrous journey of time. The narrative is suffused with science, myth, nihilism, philosophy and superstition. The book is based on the life of the Nobel Prize winning scientist, Sir Ronald Ross, who did a breakthrough research on malaria in 1989. It is an attempt to rewrite the story of Ronald Ross’s di...

BACKGROUND Malaria transmission is an extremely complex condition that is manifested differently in different parts of the world. In Pakistan, malaria is still endemic in many areas. Plasmodium vivax and Plasmodium falciparum are identified to be the most prevalent species of malaria in-Pakistan. A great deal of work regarding malarial transmission is available at regional level in Pakistan but...