UNLABELLED Tumor cells lacking the functional p53 suppressor gene may arrest at the G2 phase of the cell cycle after exposure to ionizing radiation, resulting in increased radioresistance. Methylxanthines (MTXs), such as pentoxifylline (PTX) or caffeine (CAF), can inhibit the G2-phase checkpoint arrest of damaged cells and thus radiosensitize them. However, the effect of MTX in cells irradiated...

UNLABELLED The purpose of this study was to evaluate the feasibility of modifying diuresis renography by the simultaneous administration of 99mTc-mercaptoacetyltriglycine (MAG3) and furosemide in the investigation of hydronephrosis and hydroureteronephrosis in infants and children. Two parameters were assessed: the diuretic response in normal kidneys and the ability of the F+0 study to differen...

A 71-year-old man with newly diagnosed hypertension was referred for Technetium-99m mercaptoacetyltriglycine (Tc-99m MAG3) renal scintigraphy to evaluate the recent onset of impairment in renal functions. Dynamic imaging revealed activity flow which was suspicious for aortic aneurysm (AA) with a concurrent decrease in left renal blood flow. CT angiography of the thoracoabdominal aorta confirmed...

The authors present a comparison of the findings for thallium-201 (Tl-201), Tc-99m MAG3 and Tc-99m MDP in subacute and chronic radiation nephritis in a 9-yr-old boy who was treated by radiation therapy for alveolar rhabdomyosarcoma of the left chest wall by a radiation port that partially included the left kidney. Tl-201 imaging three and six months later showed a cortical defect in the left ki...

radionuclidic techniques may provide assessment of glomerular filtration rate (gfr) effective renal plasma flow (erpf) or individual renal function. several agents were available for determination of these parameters such as ¹³¹i-oih (o-iodohippurate) and different derivatives of dads (diamidodisulfur). oih has the disadvantage of imparting a relatively high absorbed radiation dose to the patie...

RATIONALE AND OBJECTIVES Decision support systems have the capacity to improve diagnostic performance and reduce physician errors. The purpose of this study was to evaluate the use of classification and regression trees (CART) with bootstrap aggregation as a decision support system in the baseline plus furosemide (F + 20) diuresis renography protocol to determine when obstruction can be exclude...

OBJECTIVE The objective of this work was to determine the minimum administered activity of (99m)Tc-mercaptoacetyltriglycine (MAG3) needed both to estimate effective renal plasma flow (ERPF) with adequate precision and to obtain good image quality. METHODS Three groups of 10 patients each were injected with 45, 71, or 132 MBq of MAG3. Renograms and perfusion and clearance images were obtained....

OBJECTIVE The relationship between age and effective renal plasma flow (ERPF) results, as measured in nuclear medicine, is well known. This paper explores the relationships among gender, age, and ERPF measurements. After reading this paper, the nuclear medicine technologist should be able to: (a) discuss the importance of establishing normal range values for ERPF that include age and gender var...

Background: Diuretic renography using 99mTc-mercaptoacetyltriglycine (99mTc-MAG3) is a relatively non-invasive technique and has been increasingly used as reliable for the evaluation of kidney function in wide range disorders. Methods: In this retrospective study, we retrieved medical records patients referred to Radiology Department Radiology, King Abdulaziz Specialist Hospital, Taif, Saudi Ar...

extended disability and income loss . . . " To this we have to add expenses from possible anti-thyroid drugs in the interim as well as potential side effects from these medications (2). 3. The results of retreatment with radioiodide have been analyzed in some detail (J). If we define "cured" of hyperthyroidism as being euthyroid or hypothyroid, then expressions are available for describing the ...