نتایج جستجو برای: lrba deficiency
تعداد نتایج: 137277 فیلتر نتایج به سال:
BACKGROUND Clinical immunology has traditionally relied on accurate phenotyping of the patient's immune dysfunction for the identification of a candidate gene or genes for sequencing and molecular confirmation. Although this is also true for other branches of medicine, the marked variability in immune-related phenotypes and the highly complex network of molecules that confer normal host immunit...
Common variable immunodeficiency (CVID) is a primary antibody deficiency characterised by hypogammaglobulinaemia, impaired production of specific antibodies after immunisation and increased susceptibility to infections. CVID shows a considerable phenotypical and genetic heterogeneity. In contrast to many other primary immunodeficiencies, monogenic forms count for only 2-10% of patients with CVI...
Primary immunodeficiencies (PIDs) are a heterogeneous group of inherited diseases of the immune system. The definite diagnosis of PID is ascertained by genetic analysis; however, this takes time and is costly. Flow cytometry provides a rapid and highly sensitive tool for diagnosis of PIDs. Flow cytometry can evaluate specific cell populations and subpopulations, cell surface, intracellular and ...
Background IgG4-related disease (IgG4RD) is a fibro-inflammatory disorder of unknown etiology. Emerging evidence indicates that chronic inflammation in IgG4RD sustained by persistent mutual activation antigen-specific B and T lymphocytes. Targeting B-T cell co-stimulation represents, therefore, rationale therapeutic approach for IgG4RD. Objectives Threefold aim the present work was (i) to asses...
Production of cellulase from Aspergillus terreus MS105 on crude and commercially purified substrates
Aspergillus terreus MS105 was originally isolated from soil and screened for cellulase production in the presence of various carbon sources including carboxymethyl cellulose (CMC), avicel, sigmacell, filter-paper and salicin. CMC induced the production of endoglucanase (EG) and filter-paperase while the levels of β-glucosidase (BGL) were increased when salicin was present in the medium. Nature ...
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