Introduction: Although patients do not experience sever pain after laparoscopic surgery, most of them experience acute or chronic pain afterward. While conventional pain killers including NSAID and narcotics in laparoscopic surgery have specific side effects, their application is inevitable. This study compares the efficacy of local anesthetic drugs and conventional pain killers in post-operati...

the partition coefficients (p-values) of certain new potential, stereoselective, reversible, long-acting local anesthetics have been determined in an n-octanol/ phosphate buffer system. these are derivatives of 2-phenoxyethyldialkylamine hydrochloride, and almost all of them are readily soluble in water. their aqueous solutions have shown different absorption maxima, and these have been used qu...

Molecular dynamics simulations have been performed to investigate the partitioning of the volatile anesthetic halothane from an aqueous phase into a coexisting hydrated bilayer, composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipids, with embedded alpha-helical peptide bundles based on the membrane-bound portions of the alpha- and delta-subunits, respectively, of nicotinic acetylcho...

There have been some recent studies on the clinical uses of the antihistamines as local anesthetic agents (1, 2, 3, 4). These have included the use of the antihistamines as local anesthetics for minor surgical procedures, nerve blocks and spinal anesthesia. The authors have compared the particular antihistamines under evaluation to procaine and, in general, have obtained results superior to tho...

amitriptyline, a tricyclic antidepressant agent is used as one of the analgesic drugs in different kinds of pain. in the present study the effect of local (subcutaneous) injection of amitriptyline (50 and 100 µg) on the acute and chronic pain using formalin test, was investigated. our data show that local injection of amitriptyline to the paw receiving formalin, causes a decrease in pain in bot...

A relatively large group of compounds, which includes local anesthetics, antiarrhythmics, and anticonvulsants induce voltage-and/or frequency-dependent block of sodium and other ion channels. Current block increases as the stimulus voltage and frequency of depo-larization is increased. These voltage-and frequency-dependent blocking properties have been recognized for over 40 yr (Weidmann, 1955)...