Nonalcoholic fatty liver disease patients are characterized by hepatic steatosis. Prenatal glucocorticoid overexposure can result in steatosis. In this study, we aimed to determine the mechanism and cellular apoptosis of prenatal glucocorticoid overexposure in rats and whether melatonin can rescue the prenatal glucocorticoid-induced steatosis and apoptosis in neonatal rats. Pregnant Sprague-Daw...

OBJECTIVE To assess the diagnostic value of a particular set of local intensity parameters extracted from ultrasound liver images in conjunction with support vector machine (SVM) classifiers for liver steatosis grading in respect to the "gold standard" provided by liver biopsy. MATERIAL AND METHODS We prospectively enrolled in the study 228 patients with chronic hepatopathies. All the patient...

context the pnpla3 i148m variant has been recognized as a genetic determinant of liver fat content and a genetic risk factor of liver damage progression associated with steatohepatitis. the i148m variant is associated with many chronic liver diseases. however, its potential association with inflammatory and autoimmune liver diseases has not been established. evidence acquisition we systemically...

Background: Hepatic steatosis is commonly observed in patients with chronic hepatitis C (CHC). Many studies indicate a relationship between steatosis and fibrosis progression. The aim of this study was to analyze the prevalence of hepatic steatosis and related factors in Iranian CHC patients.   Methods: One hundred and fifteen consecutive patients with CHC were enrolled which were treat...

Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of tractable cellular and animal models. Steatosis also occurs in cats, where it can cause severe hepatic failure. Previous studies demonstrate the potential of liver organoids for modeling genetic diseases. To examine the possibility of using organoids to model steatosis, we established a long-term feli...

Hepatic steatosis is a commonly noticed and most prevalent condition among donated liver grafts. The pressing demand for organs and increased patient death rates while awaiting organ transplantation has led to the use of cadaveric livers with hepatic steatosis for transplantation. Recent data reported the use of steatotic liver grafts in 71% of cases (Noujaim et al., 2009). Moreover, to meet th...

OBJECTIVE To review present knowledge of the influence of hepatic steatosis in liver surgery as derived from experimental and clinical studies. SUMMARY BACKGROUND DATA Hepatic steatosis is the most common chronic liver disease in the Western world, and it is associated with obesity, diabetes, and metabolic syndrome. Fatty accumulation affects hepatocyte homeostasis and potentially impairs rec...

OBJECTIVE Sphingolipid de novo biosynthesis is related to nonalcoholic fatty liver disease or hepatic steatosis. However, the mechanism is still unclear. Sphingomyelin synthase (SMS), using ceramide as one of the substrates to produce sphingomyelin, sits at the crossroads of sphingolipid biosynthesis. SMS has 2 isoforms: SMS1 and SMS2. SMS2 is the major isoform in liver. APPROACH AND RESULTS ...

conclusions core-lds interaction may be an underlying molecular mechanism to induce liver steatosis in patients with hcv infection. this interaction is also crucial for efficient viral replication and persistence in infected cells. steatosis can also interfere with efficient standard interferon therapy treatment. management of steatosis should be considered along with standard care for achievin...

OBJECTIVE: Fatty liver deposition is a very common finding, but it has many atypical patterns of distribution that can represent diagnostic pitfalls. The purpose of this pictorial essay is to review different patterns of fatty liver deposition and sparing. METHODS: We searched our archive retrospectively, reviewed the literature, and identified six patterns of liver steatosis. RESULTS: Steato...