neous mixture of both proteins and lipids that are partially oxidized (67). It is thought that lipofuscin accumulation is a major causal factor in AMD because it correlates with the severity of photoreceptor degeneration (94) and has been shown to have toxic properties (21, 68). The major fluorescent component of lipofuscin is Nretinylidene-N-retinylethanolamine (A2E), which is a metabolite of ...

The retinal pigment epithelium contains three major types of pigment granules; melanosomes, lipofuscin and melanolipofuscin. Melanosomes in the retinal pigment epithelium (RPE) are formed during embryogenesis and mature during early postnatal life while lipofuscin and melanolipofuscin granules accumulate as a function of age. The difficulty in studying the formation and consequences of melanoso...

based on both animal and human studies, inequality in food intake and social instability has adverse effects on the health of individuals and the community. however, it is not known whether social instability, food deprivation and food inequality affect neuronal death and premature aging in young animals. to address this question, the effects of these adverse situations, histopathological chang...

Lipofuscin, which is a fluorescent pigment detectable in crustacean neural tissue, is correlated with age in laboratory populations of Homarus, Nephrops and Penaeus. In natural populations where age is unknown it is correlated with body size. In lipofuscin frequency distributions modes are present in some instances and may indicate the age structure of these populations. Lipofuscin accumulation...

A substantial portion of the lipofuscin that accumulates with age and in some retinal disorders in retinal pigment epithelial (RPE) cells, forms as a consequence of light-related vitamin A recycling. Major constituents of RPE lipofuscin are the di-retinal conjugate A2E and its photoisomers. That the accretion of A2E has consequences for the cell, with the adverse effects of A2E being attributab...

Discoloration are symptoms of skin aging. They are connected with presence of melanin and lipofuscin, whose excess and abnormal distribution in the skin cause dark spots to appear. Melanin is formed under the influence of tyrosinase during melanogenesis. Its content changes with age, which may be a result of menopause. Lipofuscin is another example of the age pigment. It is composed of proteins...

PURPOSE To compare the fluorescence properties of autofluorescent granules generated by retinal pigment epithelial (RPE) cells in vitro with those of the lipofuscin of RPE in vivo. METHODS Cultured human RPE cells were maintained in basal medium for as long as 1 year, fed rod outer segments (ROS) daily for as long as 56 days, fed ROS in the presence and absence of leupeptin, or fed liposomes ...

AIMS In a previous study, we found that prolonged oxidative stress produced by chronic ethanol consumption leads to an increased formation of lipofuscin in hippocampal and cerebellar neurons. This pigment is an end-result of lipid peroxidation. Flavanols, which abound in the human diet, are known to exert a powerful in-vitro antioxidant action. Therefore, to evaluate whether these compounds mig...

Polbax, a water-soluble extract of fresh pollen grains and pistils, was tested for its ability to influence the accumulation of lipofuscin (age pigment) in cultured neonatal rat cardiac myocytes. Exposure for 3 weeks to Polbax at concentrations of 0.1, 1.0 or 10 mg/L decreased lipofuscin accumulation morphometrically assayed using laser scanning microscopy images (green excitation light) of for...