Abstract Excess platelet activation by extracellular vesicles (EVs) results in trophoblast inflammasome activation, interleukin 1? (IL-1?) preeclampsia (PE), and partial embryonic lethality. Embryonic thrombomodulin (TM) deficiency, which causes lethality hallmarked impaired proliferation, has been linked with maternal activation. We hypothesized that placental TM loss, are mechanistically to H...

The immunomodulatory activity of Cod liver oil (CLO) was evaluated by mice lethality test, carbon clearance assay, neutrophil adhesion test, cyclophosphamide-induced neutropenia, indirect haemagglutination test and effect on serum immunoglobulin levels. CLO was administered orally at a dose of 0.5 g/kg or 1 g/kg body weight. In mice lethality test, low dose of CLO (0.5 g/kg, po) produced 40% de...

Intrinsic postzygotic reproductive isolation is thought to result from the substitution of multiple harmless or beneficial genetic differences between species that are incidentally deleterious when combined in species hybrids, causing hybrid sterility or inviability. Genetic variability for hybrid sterility or inviability phenotypes is, however, rarely assessed in natural populations. Here, we ...

An unexpected high level of acute lethality has been documented following Photofrin II-mediated photodynamic therapy (PDT) treatments which were localized to the hind leg of normal and tumor-bearing mice. Doses of PDT which induced lethality (10 mg/kg Photofrin II, 200-500 J/cm2) were in the range of doses required to obtain murine tumor cures. The percentage of lethality was proportional to th...

Vitamin A and its derivatives have recently reported to be implicated in synaptic plasticity. The possible effect of vitamin A and its precursor, ?-carotene, on seizure acquisition was tested in PTZ kindling model of epilepsy. Vitamin A and ?-carotene were tested for their ability to 1) suppress seizures (clonic and tonic) and lethality induced by PTZ in PTZ-kindled mice (anticonvulsant effect)...

the immunomodulatory activity of cod liver oil (clo) was evaluated by mice lethality test, carbon clearance assay, neutrophil adhesion test, cyclophosphamide-induced neutropenia, indirect haemagglutination test and effect on serum immunoglobulin levels. clo was administered orally at a dose of 0.5 g/kg or 1 g/kg body weight. in mice lethality test, low dose of clo (0.5 g/kg, po) produced 40% de...

A major goal in cancer medicine is to find selective drugs with reduced side effect. A pair of genes is called synthetic lethality (SL) if mutations of both genes will kill a cell while mutation of either gene alone will not. Hence, a gene in SL interactions with a cancer-specific mutated gene will be a promising drug target with anti-cancer selectivity. Wet-lab screening approach is still so c...

BACKGROUND Lower serotonergic activity correlates with high-lethality suicide attempts in major depression. Postmortem studies of serotonin receptors in suicides localize changes to the ventral prefrontal cortex (PFC). We studied serotonergic response in ventral PFC in depressed patients surviving a high-lethality suicide attempt. METHODS Depressed patients with a history of a high-lethality ...

The objective: to study changes and prognostic significance of the blood NT-proBNP in patients with pulmonary sepsis. Subjects Methods. included 34 aged 54.5 ± 2.9 years sepsis or septic shock. Lethality intensive care unit (ICU) was 47.1%. NT-proBNP, procalcitonin (PCT) levels, lactate hemodynamic parameters were registered on 1st day (stage 1) 4th-5th ICU stay 2). Hemodynamics assessed throug...