Three small families of hydrolytically stable thioaryl glycosides were prepared as inhibitors of the LecA (PA-IL) virulence factor corresponding to the carbohydrate binding lectin from the bacterial pathogen Pseudomonas aeruginosa. The monosaccharidic arylthio β-d-galactopyranosides served as a common template for the major series that was also substituted at the O-3 position. Arylthio disaccha...

Groundwater samples contaminated with potentially toxic elements (PTE), including metals and nitrate ions, were collected at a depth of 8–10 m from the Siberian Chemical Plant multicomponent waste storage. The possibility developing permeable biogeochemical barrier zeolite lightweight expanded clay aggregate (LECA) was investigated. mass fraction properties several (Mn, Fe, Co, Ni, Cu, Zn, Cd, ...

The spread of antibiotic resistant bacteria is one of the most pressing problems in human health today. In the case of the opportunistic pathogen Pseudomonas aeruginosa, which causes lethal airway infections in cystic fibrosis and immunocompromised patients, the formation of biofilms plays an important role in antibiotic resistance and disease progression. Biofilm formation is mediated in part ...

Synthetic glycopeptide dendrimers composed of a branched oligopeptide tree structure appended with glycosidic groups at its multiple N-termini were investigated for binding to the Pseudomonas aeruginosa lectins LecB and LecA. These lectins are partly responsible for the formation of antibiotic resistant biofilms in the human pathogenic bacterium P. aeruginosa, which causes lethal airway infecti...

We have previously shown that vaccination with purified Entamoeba histolytica Gal/GalNAc lectin or recombinant subunits can protect mice from intestinal amebiasis upon intracecal challenge. In this study, we demonstrated with adoptive-transfer experiments that this lectin vaccine protection is mediated by T cells but not serum. The cell-mediated immune (CMI) response was characterized by signif...

In this work we review the current knowledge on the prehistory, origins, and evolution of spliceosomal introns. First, we briefly outline the major features of the different types of introns, with particular emphasis on the nonspliceosomal self-splicing group II introns, which are widely thought to be the ancestors of spliceosomal introns. Next, we discuss the main scenarios proposed for the or...

this study was conducted to investigate the effects of irrigation frequency and substrates on some parameters of greenhouse tomato (cv. hamra) during 1381-1382 at research greenhouse of agriculture college, in ferdowsi university of mashhad. the experiment was based on split plots in the form of completely randomized design and in four replications. irrigation frequency in three levels of 12, 8...

Two force probing methods were used to quantify nanoscale forces in the interaction of bacterial lectin LecA with glycolipid Gb3, revealing how aids attachment and lowers energy required for uptake.