نتایج جستجو برای: lassa fever

تعداد نتایج: 96729  

Journal: :The Journal of infectious diseases 2013
David Safronetz James E Strong Friederike Feldmann Elaine Haddock Nafomon Sogoba Douglas Brining Thomas W Geisbert Dana P Scott Heinz Feldmann

The virulence of Soromba-R, a Lassa virus strain recently isolated from southern Mali, was assessed in 2 animal models of Lassa fever: inbred strain 13 guinea pigs and cynomolgus macaques. In both models, the Malian isolate demonstrated tissue tropism and viral titers similar to those of historical Lassa virus isolates from Sierra Leone (Josiah) and Liberia (Z-132); however, the Soromba-R isola...

2017
Trevor V Gale Timothy M Horton Donald S Grant Robert F Garry

Lassa fever afflicts tens of thousands of people in West Africa annually. The rapid progression of patients from febrile illness to fulminant syndrome and death provides incentive for development of clinical prognostic markers that can guide case management. The small molecule profile of serum from febrile patients triaged to the Viral Hemorrhagic Fever Ward at Kenema Government Hospital in Sie...

2017
Akinola Ayoola Fatiregun Elvis Efe Isere

Epidemic prone diseases threaten public health security. These include diseases such as cholera, meningitis, and hemorrhagic fevers, especially Lassa fever for which Nigeria reports considerable morbidity and mortality annually. Interestingly, where emergency epidemic preparedness plans are in place, timely detection of outbreaks is followed by a prompt and appropriate response. Furthermore, du...

Journal: :Journal of virology 2014
Marion Russier Stéphanie Reynard Xavier Carnec Sylvain Baize

UNLABELLED Lassa virus is an Old World Arenavirus which causes Lassa hemorrhagic fever in humans, mostly in West Africa. Lassa fever is an important public health problem, and a safe and effective vaccine is urgently needed. The infection causes immunosuppression, probably due to the absence of activation of antigen-presenting cells (dendritic cells and macrophages), low type I interferon (IFN)...

Journal: :PLoS Neglected Tropical Diseases 2009
Elisabeth Fichet-Calvet David John Rogers

BACKGROUND Lassa fever is caused by a viral haemorrhagic arenavirus that affects two to three million people in West Africa, causing a mortality of between 5,000 and 10,000 each year. The natural reservoir of Lassa virus is the multi-mammate rat Mastomys natalensis, which lives in houses and surrounding fields. With the aim of gaining more information to control this disease, we here carry out ...

Journal: :Journal of clinical microbiology 1994
A H Demby J Chamberlain D W Brown C S Clegg

We developed a method based on a coupled reverse transcription-PCR (RT-PCR) for the detection of Lassa virus using primers specific for regions of the S RNA segment which are well conserved between isolates from Sierra Leone, Liberia, and Nigeria. The specificity of the assay was confirmed by Southern blotting with a chemiluminescent probe. The assay was able to detect 1 to 10 copies of a plasm...

2015
John T. Manning Naomi Forrester Slobodan Paessler

Previous imported cases of Lassa fever (LF) into the United Kingdom from the Ivory Coast and Mali, as well as the detection of Lassa virus (LASV) among the Mastomys natalensis population within Mali has led to the suggestion that the endemic area for LF is expanding. Initial phylogenetic analyses arrange isolates from Mali and the Ivory Coast separately from the classical lineage IV isolates ta...

Journal: :Journal of vector borne diseases 2017
D E Agbonlahor A Erah I M Agba F E Oviasogie A F Ehiaghe M Wankasi O A Eremwanarue I J Ehiaghe E C Ogbu R I Iyen S Abbey M Y Tatfeng J Uhunmwangho

BACKGROUND & OBJECTIVES Lassa fever has been endemic in Nigeria since 1969. The rodent Mastomys natalensis has been widely claimed to be the reservoir host of the Lassa virus. This study was designed to investigate the dis- tribution of species of rodents in three states (Edo, Delta and Bayelsa) of Nigeria and to determine the prevalence of Lassa virus amongst trapped rodents in the selected st...

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2010
Daniel G Bausch Christiane M Hadi Sheik Humarr Khan Juan J L Lertora

Lassa fever is an acute viral hemorrhagic illness; the virus is endemic in West Africa and also of concern with regard to bioterrorism. Transmission of Lassa virus between humans may occur through direct contact with infected blood or bodily secretions. Oral administration of the antiviral drug ribavirin is often considered for postexposure prophylaxis, but no systematically collected data or u...

2017
Akouda Akessiwe Patassi Dadja Essoya Landoh Agballa Mebiny-Essoh Tchalla Wemboo Afiwa Halatoko Hamadi Assane Bayaki Saka Mouchedou Abdoukarim Naba Issifou Yaya Kossi Atsissinta Edou Tsidi Agbeko Tamekloe Abiba Kere Banla Kokou Mawule Davi Magloire Manga Yao Kassankogno Dominique Salmon-Ceron

Background Lassa fever belongs to the group of potentially fatal hemorrhagic fevers, never reported in Togo. The aim of this paper is to report the first two cases of Lassa fever infection in Togo. Case Presentation The two first Lassa fever cases occurred in two expatriate's health professionals working in Togo for more than two years. The symptoms appeared among two health professionals of ...

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