نتایج جستجو برای: janus kinase 2

تعداد نتایج: 2686970  

Journal: :Infection and immunity 2013
Jin Ju Lee Dong Hyeok Kim Dae Geun Kim Hu Jang Lee Wongi Min Man Hee Rhee Jae Youl Cho Masahisa Watarai Suk Kim

Brucella abortus is an intracellular pathogen that uses a crafty strategy to invade and proliferate within host cells, but the distinct signaling pathways associated with phagocytic mechanisms of B. abortus remain unclear. The present study was performed to test the hypothesis that Toll-like receptor 4 (TLR4)-linked signaling interacting with Janus kinase 2 (JAK2) plays an essential role in B. ...

2013
Yoshiaki Takahashi Ann E. Mayne Ladawan Khowawisetsut Kovit Pattanapanyasat Dawn Little Francois Villinger Aftab A. Ansari

Innate immune responses are reasoned to play an important role during both acute and chronic SIV infection and play a deterministic role during the acute stages on the rate of infection and disease progression. NK cells are an integral part of the innate immune system but their role in influencing the course of SIV infection has been a subject of debate. As a means to delineate the effect of NK...

Journal: :Pharmacology, biochemistry, and behavior 2013
Marcos García-Juárez Carlos Beyer Porfirio Gómora-Arrati Raymundo Domínguez-Ordoñez Francisco J Lima-Hernández José R Eguibar Yadira L Galicia-Aguas Anne M Etgen Oscar González-Flores

The present study tested the hypothesis that the Janus kinase 2, Src tyrosine kinases, and mitogen-activated protein kinase interact to regulate lordosis behavior induced by leptin in ovariectomized, estrogen-primed rats. The role of protein kinase A and protein kinase C in lordosis facilitation by leptin was also assessed. In experiment 1, the intracerebroventricular administration of leptin t...

2015
Mihaela I Precup Cornea Emmanuel Levrat Paul Pugin Daniel C Betticher

INTRODUCTION The World Health Organization classification of chronic myeloproliferative disease encompasses eight entities of bone marrow neoplasms, among them Breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1-positive chronic myeloid leukemia and polycythemia vera. Polycythemia vera requires, in the majority of cases (95%), the negativity of Breakpoint cluster region-A...

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