نتایج جستجو برای: itpa
تعداد نتایج: 206 فیلتر نتایج به سال:
آنزیم اینوزین تری فسفات پیروفسفاتاز (itpase) که توسط ژن itpa کد می شود عهده دار حفاظت سلول ها از طریق حذف نوکلئوتید های پورینی دآمینه سه فسفاته از مخزن نوکلئوتیدی می باشد. این نوکلئوتید های غیر طبیعی (itp، ditp، xtp) طی فرایند دآمیناسیون بازهای پورینی بوجود می آیند و به نظر می رسد افزایش غلظت و تجمع آن ها در شرایط خاصی مانند استرس برای سلول مضر می باشد و منجر به افزایش جهش ها و ناپایداری ژنتیکی...
BACKGROUND Inosine triphosphate pyrophosphohydrolase (ITPase) is a 'house-cleaning' enzyme that degrades non-canonical ('rogue') nucleotides. Complete deficiency is fatal in knockout mice, but a mutant polymorphism resulting in low enzyme activity with an accumulation of ITP and other non-canonical nucleotides, appears benign in humans. We hypothesised that reduced ITPase activity may cause acq...
Genetic polymorphisms are important factors in the effects and toxicity of chemotherapeutics. To analyze the pharmacogenetic and ethnic differences in chemotherapeutics, major genes implicated in the treatment of acute lymphoblastic leukemia (ALL) were analyzed. Eighteen loci of 16 genes in 100 patients with ALL were analyzed. The distribution of variant alleles were CYP3A4*1B (0%), CYP3A5*3 (0...
BACKGROUND To test the effect of Choice, an interactive tailored patient assessment (ITPA) tool on the number and types of symptoms addressed during consultations with cancer patients, cancer patients' active participation during consultation with clinicians, and clinicians' responses. METHOD A total of 193 consultations were audio taped and coded with the task-oriented part of Roter Interact...
ms یک بیماری خودایمنی مزمن است که در آن میلین نورون های دستگاه عصبی مرکزی (cns) آسیب دیده و آکسون ها تخریب می شوند. تخمین زده می شود که حدود 5/2 میلیون نفر در سراسر جهان به ms مبتلا باشند. ایران در ناحیه ای با شیوع متوسط قرار دارد و آمار ابتلا به آن در کشور رو به افزایش می باشد. ms یک بیماری پیچیده است و تحت تأثیر عوامل محیطی و ژنتیکی متفاوتی می باشد. یکی از داروهایی که برای بیماران ms تجویز می...
objective: one of the most significant damages to the genetic material is oxidative deamination of dna and free nucleotides in the cell pool. incorporation of deaminated purine nucleotides such as inosine triphosphate (itp, ditp) into the dna can increase the frequency of base substitution mutation. it has been suggested that presence and accumulation of these rough nucleotides can lead to gene...
conclusions in patients with chc g1 and receiving combination therapy, itpa snp-based index was an accurate and practical solution for prediction of severe anemia. background single-nucleotide polymorphisms (snp) in the inosine triphosphate pyrophosphatase (itpa) gene correlate with ribavirin (rbv)-induced anemia in patients with chronic hepatitis c (chc) receiving combination therapy. managing...
BACKGROUND A decline in hemoglobin (Hb) concentration during antiviral therapy in chronic hepatitis C (CHC) is a serious side effect. It may compel to dose reduction or even termination of antiviral treatment. The activation of erythropoietin (EPO) synthesis as a physiological response to anemia and its relation to a genetic variation within the EPO gene has not been evaluated yet. METHODS Da...
Species identification of animal tissues in meat products is an important issue to protect the consumer from illegal and/or undesirable adulteration, for economic, religious and health reasons. For example, pork DNA was found in halal chicken sausages served in a primary school in Westminster, central London, the local authority had stated on 14 March 2015. PCR is one of the most widely used te...
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