pycnocycla caespitosa is an essential oil-containing plant naturally growing in southwest of iran. the extract of this plant has been used as remedy in traditional medicine. another species of pycnocyla ( p. spinosa ) possessed antispasmodic activity. the pharmacological objective of this study was to look for relaxant effect of hydroalcoholic extract and essential oil of p. caespitosa on rat i...

Dracocephalum kotschyi Boiss. is a traditional medicine with antispasmodic activities. The objective of this research was to study antispasmodic activities of hydroalcoholic extract of D. kotschyi on rat isolated uterus contractions for comparison with isolated ileum. Hydroalcoholic extract was obtained from aerial part of D. kotschyi using percolation method. A portion of rat ileum or uterus w...

tion of smooth muscle through the action of the enteric nerve system. Clinically, pain caused by gastrointestinal spasms is generally treated with drugs that induce smooth muscle relaxation. Shakuyakukanzoto (Shaoyao-Gancao-tang, an aqueous extract of a mixture of Paeoniae Radix and Glycyrrhizae Radix) and Kanzoto (an aqueous extract of Glycyrrhizae Radix) have been used clinically to relieve g...

Aqueous extracts of cotton and other vegetable dusts cause contraction of the isolated ileum and tracheal muscle of the guinea-pig, and of isolated human bronchial muscle. The levels of this contractor activity place the dusts of cotton, flax, and jute in the order of the probable incidence of byssinosis occurring in the mills spinning these fibres. Extracts of cotton dust possess a histamine-l...

AIM To evaluate motoric intestinal disturbances during inflammation with Trichinella spiralis in rats as an experimental model. METHODS We examined the changes in worm-positive (jejunum) and worm-free (ileum) intestinal segments of rats infected with T. spiralis. To investigate the relationship between structural and functional changes in smooth muscle, we measured the thickness of the muscle...

The selective action of vincristine (VCR) has been correlated with longer retention of the drug in neoplastic tissue compared with normal tissues of the mouse (J. A. Houghton, L. G. Williams, P. M. Terranee, and P. J. Houghton, Cancer Res., 44: 582-590, 1984). In order to examine the basis for this differential, the stability of drug-protein complexes was examined further. The stability of drug...

The selective action of vincristine (VCR) has been correlated with longer retention of the drug in neoplastic tissue compared with normal tissues of the mouse (J. A. Houghton, L. G. Williams, P. M. Torrance, and P. J. Houghton, Cancer Res., 44: 582-590, 1984). In order to examine the basis for this differential, the stability of drug-protein complexes was examined further. The stability of drug...