Radiosurgery serves an important function in the treatment of patients with intraocular tumors and preserves visual function via organ conservation. Therefore, it is important to ensure the safety and precision of GK-SRS as a primary treatment for intraocular tumors. The present case study described a 57-year-old female with uveal melanoma treated with GK-SRS. Retrobulbar anesthesia following f...

PURPOSE To describe the cell of origin, tumor progression, light and electron microscopic appearance, immunohistochemical properties, and response to frequently used anticancer therapies in two transgenic models of intraocular melanoma. METHODS Two lines of transgenic mice that develop pigmented intraocular tumors were produced with the SV40 T and t antigens under the control of the mouse tyr...

purpose : to evaluate the effectiveness of chemoreduction (crd) for globe saving in patients with intraocular retinoblastoma methods : in this interventional case series all patients with intraocular retinoblastoma were included and classified according to the international classification of retinoblastoma (icrb) from group a to e. six cycles of intravenous vincristine, etoposide and carboplati...

Retinoblastoma is the most common intraocular tumor in childhood. In majority of early stage retinoblastoma, the eyeballs as well as vision can be preserved with chemotherapy and local intraocular therapy with laser or photocoagulation. However, more than half the patients in India and other developing nations present in advanced stage of the disease. This article reviews the genetics, clinical...

A 5-month-old infant with bilateral advanced retinoblastoma underwent six cycles of systemic chemotherapy. In an attempt to salvage the second eye, three serial injections of periocular carboplatin were given for persistent vitreous seeding. Following the third injection, the patient developed periocular ecchymosis and magnetic resonance imaging demonstrated abnormal signal characteristics at t...

The authors studied the role of natural killer (NK) cells in spontaneous metastasis of murine intraocular melanoma by transplanting murine B16 melanoma cells into the anterior chamber of the eye in syngeneic C57BL/6 mice and determining the number of metastatic lung tumor colonies after 40 days. Depletion of NK activity by anti-asialo GM1 serum dramatically enhanced metastasis and augmentation ...

FIZZ:: case repon on a ram inUaaular tumor. A 34 years old female plienl hat a ITat pigmented subconjunctival spa at 3 o’clock 3mm behind the limbus of her left eye for many years. Accidentally B Mafk tumor of tie ciliary body was seen at 5 o’clock. Visual acuity w 13 on bXh eyes. The irmmcular tumor tag&r with b &ml perforation was mated bu local rsection. Histology will be presented tog&w wit...

background and objectives: retinoblastoma is the most common intraocular pediatric malignancy. angiogenic factor expression such as vegf (vascular endothelial growth factor) in retinoblastoma can be confirmatory angiogenic potential of this tumor. this study was performed to determine the role of angiogenesis in local invasion of retinoblastoma and its correlation with patients’ survival. mater...

Intraocular melanomas, among the most com mon eye tumors in man, have seldom been reported in animals. This is particularly surprising in regard to the dog, a species that usually lives well into the "tumor age" and is affected by diverse neoplasms. In his "Pathology of Tumours" (1953) Willis (48) stated : ' 'I have not read of an intraocular melano ma in an animal." While reported cases are no...