Intraductal proliferative lesions of the breast including usual ductal hyperplasia (UDH), atypical ductal hyperplasia (ADH) and ductal carcinoma in situ (DCIS) are associated with increased risk, albeit of greatly different magnitudes, for the subsequent development of invasive carcinoma. Estrogen receptor α (ERα) has been widely accepted as a prognostic marker and a predictor for endocrine the...

To reveal any association between the histological type and grade of intraductal breast neoplasms and the manner of accumulation of gene alterations, eight types of gene alterations, i.e., loss of heterozygosity (LOH) on chromosomal arms 16p, 16q, 17p, 17q, and 18q, amplification of the c-erbB-2 and hst-1/int-2 genes, and mutation of the p53 gene, were examined by Southern blot analysis or sing...

Objective The sensitivity of pancreatic juice cytology for intraductal papillary mucinous neoplasm is insufficient. We evaluated the usefulness of repeated pancreatic juice cytology via an endoscopic naso-pancreatic drainage tube combined with carcinoembryonic antigen level of pancreatic juice for the diagnosis of malignant intraductal papillary mucinous neoplasm. Methods Between April 2004 and...

Intraductal papillary mucinous neoplasms (IPMN) arise from main pancreatic duct (MD-IPMN) and/or branch ducts (BDIPMN), and are characterized by intraductal papillary proliferation of mucin-producing epithelial cells exhibiting various degrees of dysplasia.1 IPMNs have a potential for malignant transformation with a well-described adenoma carcinoma sequence. We present endoscopic images from 3 ...

We present a case of liver metastasis of renal cell carcinoma (RCC) presenting as an intraductal tumor thrombus of the common bile duct. A 62-year-old man was admitted with jaundice. He had undergone right nephrectomy for RCC 8 years previously, and had been administered interferon alfa for lung, bone, and liver metastases for these 3 years. Abdominal enhanced computerized tomography (CT) discl...

OBJECTIVES Annular pancreas is a rare congenital anomaly characterized by pancreatic tissues wrapping completely or incompletely around the descending duodenum. In most patients with annular pancreas, onset occurs in early childhood. Adults with annular pancreas are prone to duodenal ulcers and pancreatitis. Intraductal papillary mucinous neoplasm (IPMN) is a type of papillary mucinous secretor...

CONTEXT Despite the recent progress of diagnostic and therapeutic modalities, survival rates of pancreatic adenocarcinoma remain poor, mainly due to late diagnosis. CASE REPORT We report the case of a 56-year-old man who was diagnosed with a symptomatic intraductal papillary mucinous tumor of the pancreas located in the uncus. This tumor was associated with a concurrent stenosis of the isthmi...

Intraductal papillary-mucinous tumors of the pancreas are a category of recently described tumors of the exocrine pancreas. They were reported for the first time in 1982 [1] when Ohashi et al., based on the findings of four cases of mucous secreting pancreatic cancer, theorized that those cases belonged to a group of tumors with different features with respect to common pancreatic cancer. Some ...

Pancreatic duct stones are found in 22 to 60 per cent of patients with chronic pancreatitis (CP). The stones can lead to obstruction of the outflow of pancreatic secretions causing increased intraductal pressure. 2 The pancreas is relatively noncompliant. Therefore the rise in intraductal pressure can induce tissue hypertension and ischemia. This can be a major factor causing pain in patients w...