Although the condition of pituitary dwarfism has been recognized for some considerable time, there is still a relative lack of published autopsy findings and the following case is reported briefly for this reason. Lack of hypophysial growth hormone (almost certainly elaborated in the alpha cells of the pars anterior) during infancy or childhood results in varying degrees of under-development wh...

Endotoxin has been shown to stimulate GH secretion in human and sheep. However, changes in hypothalamic neurohormones involved in the GH regulation by endotoxin have never been studied in vivo. In sheep it is possible to collect hypophysial portal blood (HPB) and quantify GH-releasing hormone (GHRH) and somatostatin (SRIH) secretion under physiological conditions. The purpose of this study was ...

The book reviewed here is dedicated to Dr. Bang and contains the proceedings of an "International conference on endotoxin standards and LAL use with parenteral drugs" that was held at Woods Hole in September 1981. Following the first two chapters, which include the keynote address by Dr. Bang and an excellent overview of the value and applications of the LAL test, most chapters are concerned wi...

It is indeed a great honor to be selected by the Society to receive the Hartman Award and I am most grateful. 1 was an ardent admirer of Carl Hartman from the time I first met him in the early ‘40’s at Stanford University. He was a personal friend of Joe Markee with whom I worked and whom 1 accompanied to Duke University and I had the benefit of numerous discussions while Hartman was visiting M...

The gonadotropin-ovary axis of patients with anorexia nervosa was assessed with the aim of distinguishing between an intrinsically hypophysial deficiency and pituitary malfunction secondary to hypothalamic impairment. The most consistent endocrine abnormality was low serum luteinizing and follicle stimulating hormone (LH and FSH) levels associated with depressed serum estradiol levels. Gonadotr...

Basal plasma luteinising hormone concentrations and the LH responses to LH-releasing hormone injection were higher in 11 young men after recovery from mania than in 15 control subjects. Since plasma concentrations of testosterone and sex hormone binding globulin were similar in the recovered manic compared with the control subjects, the increased LH response to LHRH is likely to have been due t...