CD47 is a membrane receptor that plays pivotal roles in many pathophysiological processes, including infection, inflammation, cell spreading, proliferation, and apoptosis. We show that activation of CD47 increases proliferation of human U87 and U373 astrocytoma cells but not normal astrocytes. CD47 function-blocking antibodies inhibit proliferation of untreated U87 and U373 cells but not normal...

Increased podocalyxin (PODXL) expression has been associated with a subset of aggressive types of cancer. To the best of our knowledge, the effect of PODXL on astrocytoma cell invasion and survival against chemotherapy agent was investigated for the first time in the present study. Overexpression and knockdown of PODXL were respectively performed in SW1783 (grade III astrocytoma) and U-87 (grad...

Glioblastomas (GBMs), the most frequent and aggressive human primary brain tumours, have altered cell metabolism, one of strongest indicators malignancy is an increase in choline compounds. Choline also a selective agonist some neuronal nicotinic acetylcholine receptor (nAChR) subtypes. As little known concerning expression nAChR glioblastoma cells, we analysed U87MG grade-IV astrocytoma line G...

MicroRNAs (miRNAs) are small, short noncoding RNAs that modulate the expression of numerous genes by targeting their mRNA. Numerous abnormal miRNA expression patterns are observed in various human malignancies, and certain miRNAs can act as oncogenes or tumor suppressors. Astrocytoma, the most common neuroepithelial cancer, represents the majority of malignant brain tumors in humans. In our pre...

Abstract Mechanisms to maintain telomere length over successive cell divisions are a requirement for cancer immortalization. Although many cancers through the activation of telomerase, ~10-15% human use telomerase-independent mechanisms maintenance, termed Alternative Lengthening Telomeres (ALT). In gliomas, ALT phenotype is associated with loss-of-function mutations in ATRX gene IDH-mutant ast...

background propolis is a natural product of bee and caffeic acid phenethyl ester (cape) is a pharmacologically important product of propolis. results cape prevented growth and proliferation of ags human gastric cancer cell line in a concentration-dependent manner with an ic50 of approximately 60 µm by a 24-hour treatment. also cape caused increased induction of apoptosis in ags cells from 1.37 ...

In humans, the targeting protein for Xenopus kinesin-like protein 2 (TPX2) is a cell cycle-associated protein, and altered TPX2 expression has been found in various malignancies. However, the contribution of TPX2 expression to astrocytoma progression is unclear. The aim of this study was to investigate TPX2 expression in human astrocytoma samples and cell lines. TPX2 protein expression was dete...

Astrocytoma cells characteristically possess high invasion potentials. Recent studies have revealed that knockdown of signal transducers and activators of transcription 3 (STAT3) expression by RNAi induces apoptosis in astrocytoma cell. Nevertheless, the distinct roles of STAT3 in astrocytoma's invasion and recurrence have not been elucidated. In this study, we silenced STAT3 using Small interf...

Background and purpose: Cancer is one of the major health challenges in the world. The efficacy of current treatments is low but their side effects are high. Cold atmospheric plasma (CAP) is a new modality for cancer treatment. This study aimed to compare the cytotoxicity effect of CAP on the cell line models of common cancers and normal cells. Materials and methods: In this experimental study...

Astroglial cells play an important role in orchestrating the migration and positioning of neurons during central nervous system development. Primary astroglia, as well as astrocytoma cells will extend long stable processes when co-cultured with granule neurons. In order to determine the function of the glial fibrillary acidic protein (GFAP), the major intermediate filament protein in astroglia ...