Malakoplakia is a pseudogranulomatous disorder secondary to an still unknown de - feet in some stages of phagocytosis.  We have reported a 3 year-old girl afflicted with this defect, who was admit­ted to Loghman Hospital' Pediatrics Department with severe pallor, abdominal mass and loonstanding history of dysentery prior to hospitalisation. Inconclusive clinical and B.M. Investigations rendered...

s 138 Correspondence: Sea-Blue Histiocytes 148

s 138 Correspondence: Sea-Blue Histiocytes 148

s 138 Correspondence: Sea-Blue Histiocytes 148

All trans-retinoic acid (ATRA) is a targeted therapy, used in Acute Promyelcytic leukemia (APL) and causes the abnormal promyelocytes to differentiate in to mature leucocytes, however their clearance in vivo is not known. ATRA has been found to be associated with hemophagocytosis, but sometimes one may find phagocytosis of differentiated cells by histiocytes without the overt manifestations of ...

Jacalin is a lectin which reacts with D-galactose. We have tested jacalin on 75 samples of different formalin- and alcohol-fixed tissues. A consistent cytoplasmic stain of the histiocytes was observed in paraffin-embedded tissues in all cases studied of reactive sinus histiocytosis, macrophages in clear centres of follicular hyperplasia, in tuberculosis granulomas and in osteoclast-like giant c...

Preliminary studies have suggested that alpha-1-antitrypsin (A1AT) is a useful immunohistochemical marker of histiocytes (monocytes/macrophages) and malignant tumours derived from them. To confirm the reliability of this marker a wide variety of benign and malignant lymphoreticular cells and tissues have been stained by the immunoperoxidase technique for A1AT and positive staining was found to ...