BACKGROUND Royal Jelly (RJ), a food item secreted by worker honeybees, is a mixture that contains protein, glucose, lipid, vitamins, and minerals; it is widely used as a commercial medical product. Previous studies have shown that RJ has a number of physiological effects, such as anti-inflammatory, antitumor, antiallergic and antioxidant activities. OBJECTIVES In the present study, the anti-i...

chalcone (1,3-diarylprop-2-en-1-one) derivatives have been introduced as selective cyclooxygenase-2 inhibitors. in the present study, anti-nociceptive and anti-inflammatory effects of eight novel compounds were evaluated in male mice and wistar rats by using the writhing and formalin-induced paw edema tests respectively. the activities of the compounds were compared with celecoxib as a referenc...

The present study was aimed to the pharmacological screening some traditional Indian medicinal plants for its anti-inflammatory activity. The methanolic and aqueous extracts of leaves of Moringa oleifera and Ocimum gratissimum were taken and evaluated for their anti-inflammatory potential using carrageenan induced hind paw edema method. The methanolic and aqueous extracts of Ocimum gratissimum ...

OBJECTIVE Crocin, as an active constituent of saffron, has many biological functions including antioxidant and anti-inflammatory activities. The present study was aimed to investigate the effects of crocin and chlorpheniramine on local edema induced by histamine. MATERIALS AND METHODS Local edema was induced by subcutaneous injection of histamine (100 μl, 0.1%) in ventral surface of right hin...

The phytochemical study using Caralluma umbellate (Asclepiadaceae) whole plant allowed the isolation of a novel C-21 steroidal glycoside, named as carumbelloside–IV. Carumbelloside –IV was evaluated in wistar rats using carraeenan induced left hind paw edema model. The isolated compound was administered in a dose dependant manner. This showed significant anti-inflammatory activity.

Anti-nociceptive, anti-inflammatory and gastroprotective activities of the known C-glycosyl flavonoid, isoorientin, were studied in rats and mice. For the anti-nociceptive activity assessment the p-benzoquinone-induced writing test, for the anti-inflammatory activity the carrageenan-induced hind paw edema model in mice, and for the gastroprotective activity the EtOH-induced ulcerogenesis model ...

BACKGROUND The study's aim was to evaluate the anti-inflammatory effect and influence on gastric mucosa after the combined administration of ketoprofen and zinc hydroaspartate (ZHA, 60 mg/kg). METHODS Antiedematous activity was determined according toWinter et al., analgesic activity according to the Randall and Selitto test, the influence on gastric mucosa in accordance to Komatsu. RESULTS...

BACKGROUND Corydalis bungeana Turcz. (CB; family: Corydalis DC.) is an anti-inflammatory medicinal herb used widely in traditional Chinese medicine (TCM) for upper respiratory tract infection, etc., but its anti-inflammatory active molecules are unknown. This study was designed to screen for the anti-inflammatory components from CB based on macrophage binding combined with HPLC. METHODS Xylen...

We assessed the effect of a novel and selective phosphodiesterase 4 (PDE4) inhibitor, ciclamilast, on chronic inflammation in adjuvant-induced arthritis (AIA), a rat model of rheumatoid arthritis (RA), and acute inflammation in the rat and mouse model of carrageenan-induced paw edema and peritonitis. Our results showed that daily oral administration of ciclamilast at 1, 3, and 10 mg/kg dose-dep...

This work has been done for the investigation of the anti-inflammatory activity of solvent extracts of dried leaves of Murraya koenigii Linn. by oral administration at dose of 100, 200 and 400 mg/kg body weight in healthy albino rats. Extracts were studied for its anti-inflammatory activity by using carrageenaninduced hind paw edema in albino rats and the mean increase in paw volume and % inhib...