Although hepatic dysfunction is common in adult-onset Still's disease (AOSD), sometimes it is difficult to differentiate hepatic dysfunction due to AOSD itself from drug-induced hepatic dysfunction. Further, myalgia often occurs in patients with AOSD; however, AOSD patients complicated with myositis are rare. We report a 43-year-old Japanese man with AOSD who developed myositis and hepatic dysf...

Both desflurane and sevoflurane have individually been reported to induce hepatic dysfunction; however hepatic dysfunction after administration of both of them separately in a single patient has not previously been reported. As their metabolites differ in nature, we considered that it would be unlikely that their combined use would cause sensitization and induce hepatic dysfunction. We report o...

diffuse hepatic inltration is an unusual form of hodgkin's disease (hd). its manifestation as progressive hepatitis or with hepatic failure is even rarer and can be difcult to diagnose. we aim to describe an unusual case of liver failure due to hd. a middle-aged woman with a 10 month history of daily febrile episodes, constitutional symptoms and strikingly high levels of serum ferritin was admi...

A study was conducted in Thailand during 2002–2005 in children with dengue shock syndrome (DSS) for associated hepatic dysfunction and its consequences. Among 38 children with DSS, 13 (34.2%) had hepatic dysfunction with a mean alanine aminotransferase level of 1466.9 U/litre compared to 83.1 U/ litre in those without it. Hepatic dysfunction occurred in 25.8% of children with dengue haemorrhagi...

Most models of liver dysfunction in sepsis use endotoxin (lipopolysaccharide; LPS) to induce a pathophysiological response. In our study published in this issue (Beno DWA, Uhing MR, Goto M, Chen Y, Jiyamapa-Serna VA, and Kimura RE. Am J Physiol Gastrointest Liver Physiol 280: G858-G865, 2001), the adverse effect of LPS on hepatic function in vivo was only significant at relatively high LPS dose...

Tacrolimus is a widely used immunosuppressive agent for the prophylaxis of graft-versus-host disease in allogeneic hematopoietic stem cell transplantation (HSCT). Since tacrolimus is primarily metabolized by the liver, hepatic dysfunction may affect its metabolism. Hepatic veno-occlusive disease (VOD) is an early complication of HSCT that results in hepatic dysfunction, suggesting that VOD may ...

OBJECTIVE To validate a cheaper and more accessible flow cytometry-based method of assessing Asialoglycoprotein Receptor (ASGPR) expression for hepatic functional reserve. STUDY DESIGN A retrospective analysis. PLACE AND DURATION OF STUDY Beijing Ditan Hospital, Capital Medical University, Beijing, from January 2011 to October 2013. METHODOLOGY Patients with Hepatocellular Carcinoma (HCC)...

OBJECTIVE To compare the relative hazard of muscle toxicity, renal dysfunction, and hepatic dysfunction associated with the drug interaction between statins and concomitant medications that inhibit the CYP3A4 isoenzyme. BACKGROUND Although statins provide important clinical benefits related to mitigating the risk of cardiovascular events, this class of medications also has the potential for s...

CONTEXT The liver as an important organ in the body has many essential functions in physiological processes. One of the major activities of liver is drug metabolism. Hepatic dysfunction affecting hepatic physiological activities, especially drug metabolism can cause many problems during anesthesia and administration of different drugs to patients. EVIDENCE ACQUISITION Studies on hepatic disor...