نتایج جستجو برای: hemoglobin f

تعداد نتایج: 360598  

Journal: :Blood 1963
C L CONLEY D J WEATHERALL S N RICHARDSON M K SHEPARD S CHARACHE

H EREDITARY PERSISTENCE OF FETAL HEMOGLOBIN is a term tentatively applied to a specific inherited anomaly manifested throughout life by the presence of large amounts of fetal hemoglobin in the erythro-cytes in the absence of anemia or clinical manifestations. The abnormality is attributable to a single autosomal genetic factor. Since the primary effect of the mutant gene is unknown, designation...

Journal: :Blood 1963
K A KIOSSOGLOU I J WOLMAN M GARRISON

AND MORTIMER GARRISON, JR. T HERE IS considerable interest currently with respect to the acid elution metho)d of Kleihauer, Braun and Betke1 for detecting cytologically those circulating erythrocytes which have an appreciable content of fetal hemoglobin (“F-containing cells” ) . The method is based on the lower solubility of alkaliresistant or fetal hemoglobin in an acid environment as compared...

Journal: :Blood 1965
L J REED T B BRADLEY H M RANNEY

By L. JUDEN REED, THOMAS B. BRADLEY, JR. AND HEu N M. RANNEY F ETAL HEMOGLOBIN, a tetramer of 2a and 2y polypeptide chains, constitutes the major hemoglobin component in newborn infants. During the first 6 months of extra-uterine life, the synthesis of y chains declines as chain synthesis increases. Adult Hb A, a tetramer of 2a and 2$ polypeptide chain accounts for over 95 per cent of the hemog...

Journal: :Paediatric respiratory reviews 2014
Santosh L Saraf Robert E Molokie Mehdi Nouraie Craig A Sable Lori Luchtman-Jones Gregory J Ensing Andrew D Campbell Sohail R Rana Xiao M Niu Roberto F Machado Mark T Gladwin Victor R Gordeuk

Sickle cell disease (SCD), caused by a mutation in the β-globin gene HBB, is widely distributed in malaria endemic regions. Cardiopulmonary complications are major causes of morbidity and mortality. Hemoglobin SS (Hb SS) represents a large proportion of SCD in the Americas, United Kingdom, and certain regions of Africa while higher proportions of hemoglobin SC are observed in Burkina Faso and h...

Journal: :The Journal of clinical investigation 1967
G R Honig

Reticulocytes from newborn infants with Rh isoimmune hemolytic disease actively incorporated radioactive amino acids in vitro into hemoglobins F and A. Approximately 50% of the reticulocytes appeared capable of synthesis of both of these hemoglobins within the same cell, as demonstrated by the selective elution technique of Betke and Kleihauer. An isoleucine analogue, L-O-methylthreonine, inhib...

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