Recent work has shown that the dialyzer mass transfer area coefficient (Ko A) for urea increases when the dialysate flow rate is increased from 500 to 800 mL/min. In this study we determined urea and creatinine clearances for two commercial dialyzers containing polysulfone hollow fibers in vitro at 37°C, a nominal blood flow rate of 300 mL/ min, and dialysate flow rates (Qd ) ranging from 100 t...

Although dialyzer reuse in chronic hemodialysis patients is commonly practiced in the United States, performance of reused dialyzers has not been extensively and critically evaluated. The present study analyzes data extracted from a multicenter clinical trial (the HEMO Study) and examines the effect of reuse on urea and b2-microglobulin (b2M) clearance by low-flux and high-flux dialyzers reproc...

BACKGROUND AND OBJECTIVES Aminoglycoside antibiotics are commonly used in chronic kidney disease stage 5 patients. The purpose of this study was to characterize gentamicin pharmacokinetics, dialytic clearance, and removal by hemodialysis and to develop appropriate dosing strategies. Design Setting, Participants, and Measurements: Eight subjects receiving chronic, thrice-weekly hemodialysis with...

The analysis of biomedical systems using mathematical models expressed as partial differential equations (PDEs) is the central theme of this book. This is done not with mathematical analysis such as theorems and proofs, but rather, through example applications to illustrate computational methods for the numerical solution of the model equations, and the details of implementing these numerical m...

A novel technique based on micro-CT scanning is developed to quantify coagulation in fibers of hemodialyzers. This objectivation is needed to allow accurate assessment of thrombogenicity of dialyzers used during hemodialysis, for example when comparing different strategies to avoid coagulation and/or fiber blocking. The protocol allowed imaging at a resolution of 25 µm, making it possible to co...

Background: It is well known that more than 90% of cancer deaths are due to metastases. However, the entire tumorigenesis process not fully understood, and it evident cells spreading from primary tumor play a key role in initiating metastatic process. Tumor proliferation invasion also elevate concentration regular irregular metabolites serum, which may alter normal function human homeostasis po...

The retention of a number of solutes that may cause adverse biochemical/biological effects, called uremic toxins, characterizes uremic syndrome. Uremia therapy is based on renal replacement therapy, hemodialysis being the most commonly used modality. The membrane contained in the hemodialyzer represents the ultimate determinant of the success and quality of hemodialysis therapy. Membrane's perf...

This study evaluated the single-pass system for the short-term dialysis treatment of dogs and cats with experimental renal failure. The hemodialyzer was equipped with a thin and highly permeable Cuprophan membrane. Four animals (two dogs and two cats) with total uretic obstruction were dialyzed twice in a one-week period. The vascular access by venipuncture of external jugular vein delivered mo...

Dialysis adequacy indices that may be used to evaluate the efficiency of small-solute removal include Kt/V, fractional solute removal (FSR), and equivalent urea clearance (EKR). To analyze possible relationships between those indices, we used the two-compartment variable-volume urea kinetic model to simulate several dialysis modalities: hemodialysis (HD) performed three times or six times weekl...

BACKGROUND There is a need to have a model to study methadone's losses during hemodialysis to provide informed methadone dose recommendations for the practitioner. AIM To build a one-dimensional (1-D), hollow-fiber geometry, ordinary differential equation (ODE) and partial differential equation (PDE) countercurrent hemodialyzer model (ODE/PDE model). METHODOLOGY We conducted a cross-section...