At the pH optimum for membrane fusion the haemagglutinin glycoprotein (HA) of the influenza virus membrane which is implicated in the fusion activity undergoes a conformational change. We have analysed the effects of this change on the antigenicity of the haemagglutinin by reacting the molecule with monoclonal antibodies of defined specificity. The results obtained indicate that specific change...

mycoplasma synoviae expressed variable lipoprotein haemagglutinin (vlha) is believed to play a major role in pathogenesis of the disease by mediating adherence and immune evasion. the aim of this study was sequencing iranian m. synoviae isolates for the detection of nucleotide variation in the m. synoviae vlha gene. using oligonucleotide primers complementary to the single-copy conserved 5´ end...

This study describes the protective efficacy of a novel influenza plasmid DNA vaccine in ferret challenge model. The rationally designed polyvalent encodes haemagglutinin and neuraminidase proteins derived from less glycosylated pandemic H1N1 (2009) H3N2 (1968) virus strains as well nucleoprotein (NP) matrix (M1 M2) different (1918) strain. Needle-free intradermal immunisation with protected fe...