The role of high serum and tissue levels of unconjegated bilirubin in the pathogenesis of the impaired urinary concentrating ability was investigated in homozygous (jj) Gunn rats with the congenital absence of hepatic glucuronyl transferase. Continuous phototherapy with blue fluorescent lights at a wave length of 460 nm or oral cholestyramine feeding or both reduced serum levels of unconjugated...

1. The biliary excretion of [(14)C]trimophonium iodide [tri[(14)C]methyl(3-hydroxyphenyl)ammonium iodide] was studied in normal Wistar animals and in jaundiced homozygous Gunn rats. 2. In normal Wistar rats small amounts of radioactivity (approx. 3% of the dose in 4h) were excreted in bile as two glucuronide conjugates, i.e. [(14)C]trimophonium glucuronide [tri[(14)C]methyl-(3-oxyphenyl)ammoniu...

When biased on the negative differential resistance regime, electroluminescence (EL) is emitted from planar GaAs heterostructure Gunn diodes due to the recombination of electrons in the device channel with holes that are generated by impact ionisation when the Gunn domains reach the anode edge. This EL forms non-uniform patterns whose intensity shows short-range intensity variations in the dire...

We present an asymptotic analysis of the Gunn effect in a driftdiffusion model—including electric-field-dependent generation-recombination processes—for long samples of strongly compensated p-type Ge at low temperature and under dc voltage bias. During each Gunn oscillation, there are different stages corresponding to the generation, motion and annihilation of solitary waves. Each stage may be ...

s | 37 Abstract Large-scale genome-wide association studies have identified susceptibility loci for schizophrenia in the gene encoding neurogranin (NRGN). Neurogranin is a neuron-specific calmodulin binding protein abundantly expressed in brain regions implicated in schizophrenia pathophysiology, such as the hippocampus and prefrontal cortex. Nrgn knockout (KO) mice were previously shown to exh...

We report new limits on the Gunn-Peterson effect at a redshift near 5 using spectroscopic observations of the z=5 Sloan Digital Sky Survey quasar, J033829.31+002156.3, made with the Low Resolution Imaging Spectrometer (LRIS) and the High-Resolution Echelle Spectrometer (HIRES) on the Keck telescopes. Lower resolution spectrophotometrically calibrated observations made with LRIS over the wavelen...

s | 33 Abstract It was reported the unconjugated bilirubin may be associated with neurotoxicity in the developing nervous system. And it is also reported that neonatal hyperbilirubinemia might be a vulnerability factor for the development of mental disorders. Individuals with schizophrenia show a significantly higher frequency of hyperbilirubinemia relative to patients with other psychiatric di...

s | 33 Abstract It was reported the unconjugated bilirubin may be associated with neurotoxicity in the developing nervous system. And it is also reported that neonatal hyperbilirubinemia might be a vulnerability factor for the development of mental disorders. Individuals with schizophrenia show a significantly higher frequency of hyperbilirubinemia relative to patients with other psychiatric di...