Semi-classical simulations of the UV-photoabsorption cross sections of adenine, guanine, cytosine, thymine, and uracil in gas phase were performed at the resolution-of-identity coupled cluster to the second-order (RI-CC2) level. With the exception of cytosine, the spectra of the other four nucleobases show a two band pattern separated by a low intensity region. The spectrum of cytosine is shape...

Awareness of the harmful effects of radiation has increased interest in finding the mechanisms of DNA damage. Radical and anion formation among the DNA base pairs are thought to be important steps in such damage [Collins, G. P. (2003) Sci. Am. 289 (3), 26-27]. Energetic properties and optimized geometries of 10 radicals and their respective anions derived through hydrogen abstraction from the W...

The use of the ammonia deprotection step to introduce (15)N labels at specific exocyclic amino positions of adenine, cytosine, guanine or 2-aminopurine of oligodeoxynucleotides is described.

Based on density functional theory (DFT) at the B3LYP level, we investigated interaction of DNA nucleobases with carbon nano-rings in armchair and zigzag shapes. Van der Waals correction was applied to describe long range term bipolar interaction. Results indicate that a net electric charge not transferred between bases nano-rings. This indicates is physical type. Outcomes show following order ...

Chronocoulometry was applied to determine charge in a monolayer of nucleolipid (1,2-dipalmitoyl-sn‑glycero-3-(cytidine diphosphate)) deposited at gold electrode surface. The immersion method used measure the potential zero interface ( E pzci ), which is sum on and Photon polarization infrared reflection absorption spectroscopy (PM-IRRAS) formation Watson-Crick complex between terminal cytidine ...

The method presented here enables the isolation of three monofunctional adducts. These are: platination of cytosine, adenine and guanosine. The three detected bifunctional complexes were: guanine N7 to N7, adenine N7 to N7 and adenine N7 to N1. A mixed bifunctional complex of guanine and adenosine and the product of polymerization of three adenines and two moieties of cis DDP were also detected...

This hypothesis can provide an opportunity to trace logically the process of the emergence of the DNA double helix. AT­enrichment in this hypothesis is main factor of evolution of DNA double helix from RNA double helix. The hypothesis that at the early stages there were just cytosine and guanine [1,2,3] makes the picture of the RNA world much poorer. It is difficult to form a great variety of t...