نتایج جستجو برای: growth enhancer
تعداد نتایج: 836026 فیلتر نتایج به سال:
A Single Oncogenic Enhancer Rearrangement Causes Concomitant EVI1 and GATA2 Deregulation in Leukemia
Chromosomal rearrangements without gene fusions have been implicated in leukemogenesis by causing deregulation of proto-oncogenes via relocation of cryptic regulatory DNA elements. AML with inv(3)/t(3;3) is associated with aberrant expression of the stem-cell regulator EVI1. Applying functional genomics and genome-engineering, we demonstrate that both 3q rearrangements reposition a distal GATA2...
Super enhancers have been shown to present a role in tumorigenesis, indicating that they could be promising therapeutic targets for cancer treatment. Long noncoding RNAs (lncRNAs) emerged as important regulators of progression. Here, the lncRNA LINC00094 cutaneous squamous carcinoma (cSCC) was examined. Elevated expression detected cSCC cell lines, compared with normal human epidermal keratinoc...
The aim of this study was to investigate if electric arc furnace (EAF) slag generated during steel production could have an application as a soil enhancer in agriculture. For that purpose, greenhouse experiment conducted on common beans (Phaseolus vulgaris) cultivated enriched with EAF (at 1% and 2% level), synthetic fertilizer (NPK), combined fertilizer, or control (untreated) soil. were expos...
in this study, two main probiotics (lactobacillus plantarum and lactobacillus delbrueckii subsp. bulgaricus) were isolated from the intestine of tor grypus and their effects on growth performance, gut microbial flora and digestive enzymes activities (i.e., α-amylase, lipase, trypsin, chymotrypsin, and alkaline phosphatase) of tor grypus (karaman, 1971) were determined. juveniles of t. grypus (n...
CTCF modulates Estrogen Receptor function through specific chromatin and nuclear matrix interactions
Enhancer regions and transcription start sites of estrogen-target regulated genes are connected by means of Estrogen Receptor long-range chromatin interactions. Yet, the complete molecular mechanisms controlling the transcriptional output of engaged enhancers and subsequent activation of coding genes remain elusive. Here, we report that CTCF binding to enhancer RNAs is enriched when breast canc...
Enhancer-gene interactions drive split In many species across the animal kingdom, male and female phenotypes differ. One such example is wing spot seen in Drosophila biarmipes flies but not flies. Galouzis Prud'homme investigate X-linked yellow gene its enhancer. Investigating genetics of trait, they found evidence that male-specific phenotype caused by a trans interaction between enhancer sile...
In addition to mutations in genes, aberrant enhancer element activity at non-coding regions of the genome is a key driver of tumorigenesis. Here, we perform epigenomic enhancer profiling of a cohort of more than forty genetically diverse human colorectal cancer (CRC) specimens. Using normal colonic crypt epithelium as a comparator, we identify enhancers with recurrently gained or lost activity ...
Transposable elements, including short interspersed repetitive elements (SINEs), comprise nearly half the mammalian genome. Moreover, they are a major source of conserved non-coding elements (CNEs), which play important functional roles in regulating development-related genes, such as enhancing and silencing, serving for the diversification of morphological and physiological features among spec...
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