Three male Beagles with low plasma luteinizing hormone and testosterone levels and spermatogenic dysfunction (SD-dogs) were given 3 weekly subcutaneous injections of a gonadotropin-releasing hormone analogue (Buserelin; GnRH-AB). The plasma T level of all of the SD-dogs increased and peaked at 4-6 weeks after the first injection. The total number of sperm and the sperm motility of the three SD-...

Teleost fishes are the 'champions' of sexual plasticity among vertebrates. Several species have two male reproductive morphs with distinct suites of behavioral, somatic, neuronal, endocrinological, and life history traits. Here, we consider recent studies of the social and neural modulation of sexual plasticity for such species with a focus on two neuropeptides, gonadotropin releasing hormone (...

High cell-surface GnRH receptor (GnRH-R) levels have been shown to have a major influence on the extent of GnRH agonist-mediated tumor growth inhibition. The ability of the GnRH agonist leuprorelin acetate (LA) to induce a post-transcriptional upregulation of GnRH-R at the plasma membrane of androgen-sensitive (LNCaP) and -insensitive (PC-3) prostate cancer (PCa) cells has been previously demon...

Photodynamic therapy (PDT) is a promising therapeutic modality which uses a photosensitizer to capture visible light resulting in phototoxicity in the irradiated region. PDT has been used in a number of pathological indications, including tumor. A key desirable feature of the photosensitizer is the high phototoxicity on tumor cells but not on normal cells. In this study, we conjugate a gonadotr...

Background: Presynchronization could enhance fertility in timed breeding programs. The best presynchronization method has to justify biological requirements and to provide practical and economic advantages. OBJECTIVES: Present study investigated the effectiveness of presynchronization with equine chorionic gonadotropin (eCG) before ovsynch (eCG-ovsynch) compared to conventional presynch-ovsynch...

Background: Leiomyoma are benign smooth muscle neoplasm’s that typically originate from the myometrium. The main objective was to evaluate the outcome of conservative surgical approach for submucous fibroid uterus is using prostaglandin preoperatively and gonadotropin releasing hormone (GnRh) in preoperative phase. Methods: Thirty eight patients who had hysteroscopic myomectomy with a resectosc...

The study was undertaken to compare the efficacy of an estradiol-17β + CIDR based protocol with the conventional ovsynch + CIDR based protocol for synchrony of wave emergence and ovulation in Murrah buffalos. In group I (n=25), on day 0 (beginning of experiment), buffaloes were administered a CIDR device (1.38 g P4) and concurrently received 1.5 mg E-17β. On day 9, the CIDR was removed and a pr...