Objectives: The herbicide glyphosate, a pesticide used in agriculture to control weeds, both food crops and other agricultural areas, has been identified as an endocrine modulator through the inhibition of aromatase activity activation estrogen receptors. present study examined effects glyphosate-based (Roundup® (GLY-BH) on sexual dimorphism rats after perinatal exposure low high GLY-BH males f...

The title peptide, N-benzyl-oxycarbonyl-β-glycylglycylglycine benzyl ester, C22H25N3O6, contains a non-proteinogenic amino acid residue, β-glycine, which is a homologated analogue of glycine. In the mol-ecular structure, β-glycine adopts an extended conformation with a trans conformation about its C(β)-C(α) bond. The second glycine residue adopts an extended conformation while the third glycine...

N(G)-Methylation of arginine residues in many nucleic-acid-binding proteins are formed post-translationally, catalysed by S-adenosylmethionine:protein-arginine N-methyltransferase in their glycine-rich and arginine-rich motifs. The amino acid sequences of the stimulator of HIV-1 TAR (Tat-responsive element) RNA-binding protein (SRB) and fibronectin also show the presence of the internal -Gly-Ar...

1. The intestinal transport mechanism for the tetrapeptide L-leucylglycylglycylglycine, Leu-GlyGly-Gly, and its relation to the transport of free Leu, Leu-Gly and Leu-Gly-Gly were investigated Lt vivo by means of jejunal perfusion in rats. 2. The rates of net Leu absorption from peptides (Leu-Gly and Leu-Gly-Gly-Gly) were significantly greater than those from the free amino acid mixtures when t...

The specificity of the cyclic AMP-dependent protein kinase was examined using two series of dodecapeptides as substrates. One series consisted of peptides of the general sequence (Gly)x-Arg-Arg-(Gly)y-Ala-Ser-Leu-Gly in which x + y = 6. The other series consisted of peptides of the sequence (Gly)x-Lys-Arg-(Gly)y-Ala-Ser-Leu-Gly in which x + y was again equal to 6. The peptides Gly-Gly-Gly-Gly-G...

The initiation of mucin-type O-glycosylation is catalyzed by a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases (ppGaNTase) (EC 2.4.1.41). By screening two mixed-stage Caenorhabditis elegans cDNA libraries, a total of 11 distinct sequence homologs of the ppGaNTase gene family were cloned, sequenced, and expressed as truncated recombinant proteins (gly-3, gly-4, gly-5a, gly-5b...

Glyburide (Gly) could inhibit NLRP3 inflammasome, as well be treated with Type 2 diabetes a common medication. Despite more and studies show that Gly influence cancer risk tumor growth, it remains unclear about the effect of in lung tumorigenesis. To evaluate whether inhibited tumorigenesis explore possible mechanisms, benzo(a)pyrene [B(a)p] plus lipopolysaccharide (LPS)-induced non-diabetes mi...