introductio: hematopoietic stem cell transplants (hsct) are considered as treatment options for patients with solid tumors. transplant numbers have changed significantly over the last decade. we have done autologous and allogeneic hsct for treatment of solid tumor patients in our center. methods: in order to show the transplant effect on solid tumor treatment, we collected data from 71 patients...

background: burkitt lymphoma is a common subtype of non-hodgkin lymphoma in children. it has a rapid and aggressive clinical course with frequent involvement of bone marrow and central nervous system. systemic chemotherapy is the mainstay of the treatment for this malignancy in children. in this systematic review, we discuss autologous and allogeneic hematopoietic stem cell transplantation (hsc...

INTRODUCTION Patients faced with infertility due to spermatogonial stem cell loss have currently semen cryobanking as only option for fertility preservation. A growing group of patients cannot benefit from this strategy as they are devoid of spermatozoa or even of any spermatogenic cell at the time of diagnosis. We therefore aimed at investigating alternative strategies to preserve or restore f...

The continuous production of mammalian sperm is maintained by the proliferation and differentiation of spermatogonial stem cells, which originate from primordial germ cells in the early embryo. Previously, we reported that the transplantation of fetal male gonadal tissue into the recipient testis was effective obtaining functional sperm. This transplantation technique is a promising new approac...

In recent years, the scientific community has become increasingly interested in spermatogonia. Methodological breakthroughs, such as germ cell transplantation and spermatogonial culture combined with novel germ line transfection strategies, have provided interesting new opportunities for studying the physiology of spermatogonial stem cells and their interaction with the stem cell niche. Further...

background: niche cells, regulating spermatogonial stem cells (sscs) fate are believed to have a reciprocal communication with sscs. the present study was conducted to evaluate the effect of ssc elimination on the gene expression of glial cell line-derived neurotrophic factor (gdnf), fibroblast growth factor 2 (fgf2) and kit ligand (kitlg), which are the main growth factors regulating sscs deve...

Germ cell transplantation, a powerful assisted reproductive technology, is widely used to study the functional characterization of stem cells. The technology is also used for conservation and propagation of elite germlines. In teleost fish model, the technique has been successfully established to generate donor-derived gametes by transplanting primordial germ cells (PGC) or spermatogonial cells...