نتایج جستجو برای: gcb pwm

تعداد نتایج: 4927  

Journal: :Blood 2009
Kieron Dunleavy Stefania Pittaluga Myron S Czuczman Sandeep S Dave George Wright Nicole Grant Margaret Shovlin Elaine S Jaffe John E Janik Louis M Staudt Wyndham H Wilson

Gene expression profiling of diffuse large B-cell lymphoma (DLBCL) has revealed distinct molecular subtypes that include germinal center B cell-like (GCB) and activated B cell-like (ABC) DLBCL. ABC DLBCL has a worse survival after upfront chemotherapy and is characterized by constitutive activation of the antiapoptotic nuclear factor-kappa B (NF-kappaB) pathway, which can inhibit chemotherapy. ...

Journal: :British journal of industrial medicine 1991
K E Thomas C J Trigg P J Baxter M Topping J Lacey B Crook P Whitehead J B Bennett R J Davies

After several cases of occupational asthma had been reported in a coffee processing factory in England, 197 coffee workers representing 80% of the production workforce were studied to determine the factors affecting the development of work related respiratory symptoms of wheeze, cough, and dyspnoea. Two computer administered questionnaires concerning the presence of respiratory symptoms and the...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Ching-Hung Lin Kuan-Ting Kuo Shih-Sung Chuang Sung-Hsin Kuo Julia Hueimei Chang Kung-Chao Chang Hui-Chen Hsu Hwei-Fang Tien Ann-Lii Cheng

PURPOSE Whether diffuse large B-cell lymphoma (DLBCL) of primary central nervous system origin (PCNSL) is biologically different from DLBCL of peripheral nodal origin (NL) remains unclear. The purpose of this study was to compare the expression frequencies and prognostic significance of a panel of cell differentiation markers between these two disease entities. EXPERIMENTAL DESIGN This study ...

2016
Shuangtao Zhao Xiaoli Dong Wenzhi Shen Zhen Ye Rong Xiang

Gene expression profiling (GEP) had divided the diffuse large B-cell lymphoma (DLBCL) into molecular subgroups: germinal center B-cell like (GCB), activated B-cell like (ABC), and unclassified (UC) subtype. However, this classification with prognostic significance was not applied into clinical practice since there were more than 1000 genes to detect and interpreting was difficult. To classify c...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2012
L de Leval C Bonnet C Copie-Bergman L Seidel M Baia J Brière T J Molina B Fabiani T Petrella J Bosq C Gisselbrecht R Siebert H Tilly C Haioun G Fillet P Gaulard

BACKGROUND Diffuse large B-cell lymphomas (DLBCLs) arising in specific extranodal sites have peculiar clinicopathologic features. PATIENTS AND METHODS We analyzed a cohort of 187 primary Waldeyer's ring (WR) DLBCLs retrieved from GELA protocols using anthracyclin-based polychemotherapy. RESULTS Most patients (92%) had stage I-II disease. A germinal center B-cell-like (GCB) immunophenotype w...

Journal: :Blood 2011
Gonzalo Gutiérrez-García Teresa Cardesa-Salzmann Fina Climent Eva González-Barca Santiago Mercadal José L Mate Juan M Sancho Leonor Arenillas Sergi Serrano Lourdes Escoda Salomé Martínez Alexandra Valera Antonio Martínez Pedro Jares Magdalena Pinyol Adriana García-Herrera Alejandra Martínez-Trillos Eva Giné Neus Villamor Elías Campo Luis Colomo Armando López-Guillermo

Diffuse large B-cell lymphomas (DLBCLs) can be divided into germinal-center B cell-like (GCB) and activated-B cell-like (ABC) subtypes by gene-expression profiling (GEP), with the latter showing a poorer outcome. Although this classification can be mimicked by different immunostaining algorithms, their reliability is the object of controversy. We constructed tissue microarrays with samples of 1...

Journal: :PeerJ PrePrints 2015
Martin Eisenacher Jörg Rahnenführer Axel Mosig Sven Rahmann

Autoimmune diseases arise from an abnormal immune response of the body against self-proteins leadingto tissue and organ damage. The excessive production of harmful autoantibodies (AAB) is a hallmarkof autoimmune diseases including Rheumatoid Arthritis (RA), Systemic Lupus Erythematodes (SLE),Systemic Sclerosis (SSc) and Sjögren’s Disease (SjS). Early diagnosis of autoimmune diseases...

Journal: :International journal of clinical and experimental medicine 2015
Chongyang Wu Xiangyang Wu Xiaoni Zhang Ye Chai Qi Guo Lijuan Li Lingling Yue Jun Bai Zhiping Wang Liansheng Zhang

OBJECTIVE The revised International Prognostic Index (R-IPI) aids in predicting the prognosis of patients with diffuse large B cell lymphoma (DLBCL), but R-IPI yields no significant differences in assessing different subtypes of DLBCL. It is necessary to identify patients with a high-risk of DLBCL and alternative therapy should be delivered as early as possible. METHODS In total, 144 patients...

Journal: :The American journal of pathology 2004
Javeed Iqbal Warren G Sanger Douglas E Horsman Andreas Rosenwald Diane L Pickering Bhavana Dave Sandeep Dave Li Xiao Kajia Cao Quiming Zhu Simon Sherman Christine P Hans Dennis D Weisenburger Timothy C Greiner Randy D Gascoyne German Ott H Konrad Müller-Hermelink Jan Delabie Rita M Braziel Elaine S Jaffe Elias Campo James C Lynch Joseph M Connors Julie M Vose James O Armitage Thomas M Grogan Louis M Staudt Wing C Chan

Gene expression profiling of diffuse large B-cell lymphoma (DLBCL) has revealed prognostically important subgroups: germinal center B-cell-like (GCB) DLBCL, activated B cell-like (ABC) DLBCL, and primary mediastinal large B-cell lymphoma. The t(14;18)(q32;q21) has been reported previously to define a unique subset within the GCB-DLBCL. We evaluated for the translocation in 141 cases of DLBCL th...

2017
Yukiko Nishi Riko Kitazawa Ryuma Haraguchi Ayaka Ouchi Yasuo Ueda Yuri Kamaoka Ken Yamamoto Yasuhiko Todo Hiroaki Miyaoka Sohei Kitazawa

Primary extranodal malignant lymphoma of the thyroid is a rare entity composed of mostly neoplastic transformation of germinal center-like B cells (GCB) or memory B cells. Other B-cell-type malignancies arising primarily in the thyroid have rarely been described. Immunohistochemical examination of autopsied primary malignant lymphoma of the thyroid in an 83-year-old Japanese female revealed the...

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