oral ph sensitive drug delivery systems are of utmost importance as these systems deliver the drug at specific part of the gastrointestine (gi) as per the ph of gi, resulting in improved patient therapeutic efficacy and compliance. the ph range of fluids in various segments of the gi tract may provide environmental stimuli for drug release. the aim of this study was to design buoyant beads cont...

BACKGROUND Evaluation of gastric pH and motility in a porcine model of acute lung injury using a novel, wireless motility capsule. MATERIAL/METHODS A motility capsule was applied into the stomach of 7 Pietrain pigs with acute lung injury induced by high volume saline lavage. Wireless transmission of pH, pressure and temperature data was performed by a recorder attached to the animal's abdomen...

introduction: it has been reported the alkaline response of pancreas to duodenal acidification is partly mediated through duodenal release of h2s, but till now the effect of duodenal acidification on gastric h2s release has not been investigated. therefore, the present study designed to evaluate the effects of duodenal acidification on gastric h2s release and level of mrna expression of cystath...

BACKGROUND AND OBJECTIVES During laparoscopy, the increase of the carbon dioxide tension may increase the synthesis of hydrochloric acid in the parietal cells of the stomach; the source of the secreted hydrogen ions is carbonic acid derived from the hydration of carbon dioxide. The present report tests this hypothesis by correlating the changes of end-tidal PCO2 (ETCO2) with the pH of the gastr...

In 20 patients studied under general anaesthesia, we found good agreement between gastric fluid volumes aspirated blindly and total volumes determined by fibreoptic gastroscopy (mean under-estimation 6 ml (22%); range 0-50 ml). Gastric fluid acidity measurements using an electronic pH meter and pH indicator paper also provided results with good agreement (mean difference in pH 0.1; range -0.3 t...

About 1.5-6 % of the patients with gastric and duodenal erosions admitted to I.C.U. are prone to gastrointestinal (G.I.) bleeding with its ensuing complications. Routine prophylaxis with H2-blockers and anti-acid has been used in these high risk patients for decades.In this study we evaluated the effect of P.O omeprazole, a potent acid inhibitor with prolong effects on gastric pH.  Patients wit...

Resting gastric juice and extracts of uninvaded gastric mucosa from the stomachs of patients with gastric adenocarcinomata digest plasma protein with either two or three maxima below pH 5. Egg albumen is digested with one or two maxima below pH 5, for the maximum found near pH 3.5 with plasma protein is absent. These properties do not differ significantly from those described in normal subjects...

BACKGROUND The clinical significance of Helicobacter pylori antibody titer has been controversial, and the association between the extent of gastric atrophy or acid secretion and H. pylori antibody concentration has not been elucidated. MATERIALS AND METHODS Serum pepsinogen, H. pylori antibody concentration, and fasting gastric pH (as an indicator of acid secretion) were measured in 231 pati...

OBJECTIVES Oesophageal pH monitoring is the gold standard technique for the detection of gastro-oesophageal reflux in adults and children. A standard parameter used to define "abnormal" reflux is the percentage of recording time for which the gastric pH is < 4. This study investigated the relevance of this measure in infants on regular milk feeds whose gastric contents and refluxate will be neu...

The human pathogen Helicobacter pylori has infected more than half of the world's population. Nevertheless, the first step of infection, the acute colonization of the gastric mucus, is poorly understood. For successful colonization, H. pylori must retain active motility in the gastric lumen until it reaches the safety of the mucus layer. To identify the factors determining the acute colonizatio...