Effects of DQ-2511, a new peripherally acting anti-ulcer agent, on vagally induced gastric acid output and mucosal blood flow (MBF) were investigated in urethane-anesthetized rats with gastric fistula. Intravenous infusion of DQ-2511 (2 or 20 mg/kg/hr, for 30 min) reduced the vagally induced gastric acid output and MBF, and these inhibitory effects were abolished by pretreatment with phentolami...

sub chronic exposure to lead in rats slows gastric emptying, but little is known about the effects of lead on gastric secretion. this study was designed to investigate the effects of lead on gastric acid secretion and its possible mechanisms in rats. lead acetate was dissolved in drinking water in a concentration of 1%. sodium acetate-containing water with a molar concentration similar to lead ...

Objective(s) The liver has major role in the organism homeostasis, interactions with other systems, synthesis and metabolism of bile production, drug detoxification and hormone inactivation. Cholestasis can be defined as an impairment of the bile flow which can lead to hepatocytes necrosis and finally cirrhosis. Some studies reported a gastric acid secretion reduction in cirrhotic subjects, wh...

it is well established that the esophageal distention (ed) leads to gastric relaxation, partly by vago-vagal reflex, but till now, the effect of ed on gastric acid secretion has not been investigated. the aim of this study was to investigate the effect of ed on basal and stimulated gastric acid secretion. methods: adult male wistar rats (200-240 g) were deprived of food but not the water 24 h b...

background: opioid peptides and their receptors are present in the majority of body tissues including gastrointestinal tract.  heroin is one of the opioid derivatives that abuse increasingly today.  so far, there is no study on the effect of acute heroin administration on gastric acid and pepsin secretion.   objective:  to define the effect of the acute heroin consumption on basal and vagal-sti...

AIM To investigate the effects of nesfatin-1 on gastric function in obese rats. METHODS The obese rat model was induced by a high-fat diet. The gastric emptying rate and gastric acid secretory capacity of the rats were determined after treatment with different drug concentrations of nesfatin-1 and administration routes. Based on this, the expression of H+/K+-ATPase was measured using RT-PCR a...

Aim: The aim of this study was to investigate the effect of nesfatin-1 signaling in the ventromedial hypothalamus (VMH) on gastric functions, as well as the regulation of these effects by nucleus accumbens (NAc) projections to VMH. Methods: The expression of c-fos in nesfatinergic VMH neurons induced by gastric distension (GD) was measured using the double fluoro-immunohistochemical staining. T...

objective(s) the liver has major role in the organism homeostasis, interactions with other systems, synthesis and metabolism of bile production, drug detoxification and hormone inactivation. cholestasis can be defined as an impairment of the bile flow which can lead to hepatocytes necrosis and finally cirrhosis. some studies reported a gastric acid secretion reduction in cirrhotic subjects, whi...

objective: acorus calamus (a. calamus) has been used as a medicinal plant in asia for its effects on digestive system for the last 2000 years. to investigate the anti-cancer activity of rhizome of a. calamus, the ethanolic and methanolic extracts and essential oil of the rhizome were prepared and their effects were assessed on human gastric cancer cell line (ags). materials and methods: the via...

Licorice extracts have been widely used in herbal and folk medications. Glycyrrhiza contains diverse range of biological compounds including triterpenes (glycyrrhizin, glycyrrhizic acid) and flavonoids (quercetin, liquiritin, liquiritigenin, glabridin, licoricidin, isoliquiritigenin). The flavonoids in licorice are known to have strong anti-cancer activities. Quercetin, the most abundant flavon...