Effects of REM sleep (REMs) deprivation on the basal swimming activity and the tricyclic anti-depressants-induced increase in swimming activity in the forced swimming test were investigated. Immediately after a 48-hr period of REMs deprivation, the basal swimming activity in REMs-deprived mice was significantly higher than those in group-housed and socially isolated animals used as the control ...

Antidepressant-Like Effects of Menthol via Dopaminergic System; Using Forced Swimming Test in a Mice Model

objective: the present study was designed to investigate the putative antidepressant effects of crocin and crocetin, two major active ingredients of crocus sativus l. (saffron) using mice in two different regimens of acute and sub-acute administration. material and methods: in acute treatment, antidepressant-like activities of crocin and crocetin (10, 20 and 40 mg/kg, i.p.) were evaluated using...

asperugo procumbents l. has been used in iranian traditional medicine for the refreshing, tranquillizing and mood elevating activities. the present study was undertaken to evaluate the antidepressant and sedative-hypnotic potential of acute administration of the hydroalcoholic extract of this plant in mice.additionally, the effects of flumazenil on the hypnotic activity of the extracts were eva...

withania somnifera (ws) possess anti-inflammatory and antioxidant properties. ws preparations have a potential therapeutic role in the central nervous system (cns) related disorders in animal models. in this study, the possible protective effect of acute aqueous ws root extract on behavioral despair was explored and compared with fluoxetine, an antidepressant with selective serotonin (5-ht) reu...

Background: Sports, hypothermia and hyperthermia as some stressors inhibit male reproductive functions and are associated with subfertility or infertility. We investigated whether water temperature and chronic swimming are effective on mouse sperm parameters. Materials and Methods: Adult male mouse(N=35) were randomly divided into 7 groups: 1-controls 2-cold water (100C) with swimming 3- cold w...

Forced swimming test is used to induce a characteristic behavior of immobility in rats, which resembles depression in humans to some extent. We evaluated the effect of omega-3 fatty acids alone as well as compared it with the standard antidepressant therapy with fluoxetine in both acute and chronic studies. In both the studies, rats were divided into 4 groups and subjected to the following drug...

BACKGROUND Young green barley leaf is one of the richest sources of antioxidants and has been widely consumed for health management in Japan. In this study, we examined whether oral administration of young green barley leaf has an antidepressant effect on the forced swimming test in mice. MATERIALS AND METHODS Mice were individually forced to swim in an open cylindrical container, one hour af...

Recently, we reported that a centrally acting non-narcotic antitussive (cough suppressant drug), tipepidine produces an antidepressant-like effect in the forced swimming test in rats. Because pharmacological properties of tipepidine apparently differ from those of typical antidepressants developed to date, we speculated that caramiphen, another centrally acting antitussive, has an antidepressan...

PURPOSE To compare the effects of the antidepressant drugs duloxetine and amitriptyline on depressive behaviors in rats. METHODS Fifteen male Wistar rats were given systemic injections of duloxetine, amitriptyline or saline prior to a Forced Swimming Test (FST). Immobility and number of stops were measured. Data were analyzed by one-way ANOVA and Kruskall-Wallis. RESULTS Rats given injectio...