An isocratic, reversed-phase liquid chromatographic (RP-LC) method was developed for the quantitative determination of oxcarbazepine, used in the treatment of epilepsy. This method can be also employed for the related substance determination in bulk samples. Forced degradation studies were performed on bulk sample of oxcarbazepine using acid (1.0 N hydrochloric acid), base (0.1 N sodium hydroxi...

Oxidative stress has been associated with diverse diseases, including obesity, cancer and neurodegeneration. In fact, Valeriana jatamansi Jones (valerian) and its extracts possess strong antioxidant activities that extend their application in clinical practice to the treatment of these illnesses, even though the underlying mechanisms are not well understood. Iridoid valepotriate, a characterist...

The "Dust Bowl" drought of the 1930s was highly unusual for North America, deviating from the typical pattern forced by "La Nina" with the maximum drying in the central and northern Plains, warm temperature anomalies across almost the entire continent, and widespread dust storms. General circulation models (GCMs), forced by sea surface temperatures (SSTs) from the 1930s, produce a drought, but ...

Ornithine decarboxylase (ODC) is a key enzyme in polyamine biosynthesis. It is a short-lived protein and negatively regulated by its products, polyamines. Its degradation is accelerated by the binding of antizyme, an ODC-inhibitory protein induced by polyamines. To evaluate the physiological importance of antizyme we examined the effect of forced expression of antizyme on cellular ODC and polya...

The objective of current study was to develop a validated specific stability indicating reversed-phase liquid chromatographic method for the quantitative determination of desvenlafaxine in bulk sample and pharmaceutical dosage form in the presence of degradation products. Forced degradation studies were performed on bulk sample of desvenlafaxine as per ICH prescribed stress conditions using aci...