نتایج جستجو برای: fimh hlya

تعداد نتایج: 764  

2015
Marta Kuźmińska-Bajor Krzysztof Grzymajło Maciej Ugorski

We have recently shown that Salmonella Gallinarum type 1 fimbriae with endogenous mannose-resistant (MR) variant of the FimH protein increase systemic dissemination of S. Gallinarum and colonization of internal organs in comparison to the S. Gallinarum fimH knockout strain or the mutant expressing mannose-sensitive (MS) FimH variant from S. Enteritidis. Elaborating from these studies, we propos...

Journal: :The Southeast Asian journal of tropical medicine and public health 2014
Boonnapa Kanoktippornchai Chariya Chomvarin Chariya Hahnvajanawong Thitima Nutrawong

Vibrio cholerae non-O1/non-O139 is capable of producing sporadic outbreaks of cholera-like diarrhea; however, the pathogenic mechanisms of this bacterium remain unclear. The objectives of this study were to: 1) compare the apoptosis induction and cytotoxicity between hlyA-positive and hlyA-negative strains of V. cholerae non-O1/non-O139; 2) clarify the molecular mechanisms by which these strain...

2014
Daniela A López-Banda Erika M Carrillo-Casas Margarita Leyva-Leyva Gabriel Orozco-Hoyuela Ángel H Manjarrez-Hernández Sara Arroyo-Escalante David Moncada-Barrón Silvia Villanueva-Recillas Juan Xicohtencatl-Cortes Rigoberto Hernández-Castro

E coli isolates (108) from Mexican women, clinically diagnosed with urinary tract infection, were screened to identify virulence genes, phylogenetic groups, and antibiotic resistance. Isolates were identified by MicroScan4 system; additionally, the minimum inhibitory concentration (MIC) was assessed. The phylogenetic groups and 16 virulence genes encoding adhesins, toxins, siderophores, lipopol...

Journal: :Journal of bacteriology 2000
T S Hamrick S L Harris P A Spears E A Havell J R Horton P W Russell P E Orndorff

Five Escherichia coli type 1 pilus mutants that had point mutations in fimH, the gene encoding the type 1 pilus adhesin FimH, were characterized. FimH is a minor component of type 1 pili that is required for the pili to bind and agglutinate guinea pig erythrocytes in a mannose-inhibitable manner. Point mutations were located by DNA sequencing and deletion mapping. All mutations mapped within th...

Journal: :Journal of clinical microbiology 2017
Louise Roer Veronika Tchesnokova Rosa Allesøe Mariya Muradova Sujay Chattopadhyay Johanne Ahrenfeldt Martin C F Thomsen Ole Lund Frank Hansen Anette M Hammerum Evgeni Sokurenko Henrik Hasman

The aim of this study was to construct a valid publicly available method for in silico fimH subtyping of Escherichia coli particularly suitable for differentiation of fine-resolution subgroups within clonal groups defined by standard multilocus sequence typing (MLST). FimTyper was constructed as a FASTA database containing all currently known fimH alleles. The software source code is publicly a...

2017
Said Rabbani Eva-Maria Krammer Goedele Roos Adam Zalewski Roland Preston Sameh Eid Pascal Zihlmann Martine Prévost Marc F. Lensink Andrew Thompson Beat Ernst Julie Bouckaert

The most prevalent diseases manifested by Escherichia coli are acute and recurrent bladder infections and chronic inflammatory bowel diseases such as Crohn's disease. E. coli clinical isolates express the FimH adhesin, which consists of a mannose-specific lectin domain connected via a pilin domain to the tip of type 1 pili. Although the isolated FimH lectin domain has affinities in the nanomola...

2014
Roland Benz Elke Maier Susanne Bauer Albrecht Ludwig

Escherichia coli α-hemolysin (HlyA) is a pore-forming protein of 110 kDa belonging to the family of RTX toxins. A hydrophobic region between the amino acid residues 238 and 410 in the N-terminal half of HlyA has previously been suggested to form hydrophobic and/or amphipathic α-helices and has been shown to be important for hemolytic activity and pore formation in biological and artificial memb...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه تربیت مدرس 1388

عفونت دستگاه ادراری یکی از شایعترین عفونت¬ها در انسان محسوب می¬شود و سویه¬های اشریشیا کلی یوروپاتوژن شایعترین عامل آن هستند. این سویه¬ها در مثانه کلونیزه شده و باعث سیستیت می¬شوند اما می¬توانند به سمت کلیه¬ها حرکت کنند و عامل پیلونفریت شوند. از آنجائیکه پروتئین fimh در کلونیزاسیون سویه¬های upec و ایجاد عفونت نقش بسیار مهمی دارد تهیه واکسن حاوی این ادهسین¬ مورد توجه است. در تحقیق حاضر، ادهسین fi...

Journal: :Molecular biology and evolution 2004
Evgeni V Sokurenko Michael Feldgarden Elena Trintchina Scott J Weissman Serine Avagyan Sujay Chattopadhyay James R Johnson Daniel E Dykhuizen

Spread of biological species from primary into novel habitats leads to within-species adaptive niche differentiation and is commonly driven by acquisition of point mutations in individual genes that increase fitness in the alternative environment. However, finding footprints of adaptive niche differentiation in specific genes remains a challenge. Here we describe a novel method to analyze the f...

Journal: :Applied and environmental microbiology 1998
M A Schembri P Klemm

The FimH adhesin of Escherichia coli type 1 fimbriae confers the ability to bind to D-mannosides by virtue of a receptor-binding domain located in its N-terminal region. This protein was engineered into a heterobifunctional adhesin by introducing a secondary binding site in the C-terminal region. The insertion of histidine clusters into this site resulted in coordination of various metal ions b...

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